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The Efficacy and side effects of different doses of finastride/ dutastride accompanying with tamsulosin for Benign prostate hyperplasia in Iranian men
Study aim: 1- the comparison of QMAX(maximal flow rate) ,IPSS SCORE( international prostate symptom score) ,SDI SCORE(sexual desire inventory),IIEF15(international index of erectile function) before, 3 and 6 months after treatment in each group and between five groups in this study Design: randomized ,parallel group trial with blinded outcome assessment .Randomisation was centralised and computerised with concealed randomisation sequence carried out at an external site Settings and conduct: this study is performed by urology research center in shahid beheshti university of medical sciences.This study include 5 groups .group one is considered as a control group .The finastride 5mg and 3mg , dutastride 0.5mg and 0.25mg and placebo tablets are identical in appearance and prepared by tansnim company. QMAX , IPSS score , IIEF15 score, SDI score are assessed before , 3 and six months after treatment . the complication of drug was assessed in each group .investigator, care provider, patients, data analyzer , outcome assessor were all blinded . Participants/Inclusion and exclusion criteria: inclusion criteria :prostate size larger than 30 cc, moderate to sever IPSS score . exclusion criteria: PSA more than 4 ng/dl., history of bladder or prostate cancer, history of prostate surgery, history of urethral stricture Intervention groups: group one take tamsulosin 0.4mg once daily and placebo ,group 2 take tamsulosin 0.4mg daily and finasteride 5mg once daily , group 3 take one capsule of tamsulosin 0.4mg and finasteride 3mg once daily , group 4 take one capsule of tamsulosin 0.4mg and dutastride 0.25mg once daily , group 5 take one capsule of tamsulosin 0.4mg and dutastride 0.5mg once daily . Main outcome variables: QMax, IPSS SCORE .IIEF15 SCORE . SDI SCORE
IRCTID: IRCT20120516009772N2
  1. The efficacy of combination therapy with "Tamsulosin and Meloxicam” for the management of Lower Urinary Tract Symptoms suggestive of Benign Prostatic HyperplasiaL: a randomized double-blind placebo–control clinical trial
  2. The study of the effect of tadalafil in comparison with tamsulosin and placebo on the symptoms of double-J stent insertion in ureteral following by transureteral ureteroscopy and lithotripsy in men with ureteral stones
  3. Comparison the effect of tadalafil 20 mg alone and tadalafil 5 mg with tamsulosin on erectile dysfunction in diabetic patients
  4. Effect of combination therapy of coenzyme Q10 and L carnitine and finasteride on treatment management in patients with lower urinary tract symptoms ( LUTS) due to benign prismatic hyperplasia (BPH)
  5. Comparative study on the effectiveness and safety of tamsulosin Oral-Controlled Absorption System (OCAS®) with tamsulosin Modified Release (MR) and placebo in improving lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH)
  6. the Effectiveness of Different Tamsulosin Doses on Lower Urinary Tract Symptoms in Patients with Benign Prostatic Hyperplasia
  7. Comparison of ultrasonography and uroflowmetry index in diagnosis of bladder outlet obstruction in patients with lower urinary tract symptom due to benign prostatic hyperplasia
  8. Evaluation and comparison of the effect of Tadalafil and placebo on nighttime frequency refractory to treatment with alfa-adrenergic inhibitors in males with LUTS/BPH referred to Razi Hospital
  9. Evaluation of efficacy and complications of prostatic arterial embolization in the treatment of BPH
  10. Comparison the effect of Cucumis Melo L seeds oral product and Tamsulosin with Tamsulosin and placebo in reducing the symptoms of patients with benign prostatic hypertrophy.
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