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Study aim:
Does the addition of long-acting subcutaneous insulin to the standard treatment of diabetic ketoacidosis reduce the time out of the acute phase?
Design:
after providing a full explanation of the method and purpose of the research, the children's parents sign the consent form and the basic information is entered into a questionnaire. This information includes Age, weight, height, stage of puberty, history and severity of the disease .Patients are divided into one of the control and intervention groups using random block sampling method.Control group: receive short-term insulin drip (standard treatment).
Intervention groups: In addition to receiving standard short-term insulin drip, they receive a long-acting subcutaneous insulin dose of 0.5 units per kilogram of child weight.In both groups,Time out of the acute phase and the occurrence of complications are recorded. Leaving the acute phase, ie serum pH level> 7.3 and HCO3> 15mEq / L, normal serum electrolytes, alertness and no vomiting. Blood glucose levels are measured and recorded by the glucometer every hour and the patients' blood glucose, sodium, potassium and VBG are measured every three hours.The results are compared and statistically analyzed in two groups.
Settings and conduct:
Patients in all groups will be admitted to PICU from the time of admission to the time of exit from the acute phase and will be monitored continuously for possible complications and will be treated in case of complications.
Participants/Inclusion and exclusion criteria:
nclusion criteria:
1• The patient is between 2 and 15 years old.
2• Children with acute diabetic ketoacidosis :
o BS> 200 mg / dL
o PH <7.30
o HCO3 <15 mEq /L
o Urine ketone is positiv
Intervention groups:
intervention groups: Adding two types of long-acting subcutaneous insulin to standard treatment of DKA
Main outcome variables:
Time to exit the acute phase of diabetic ketoacidosis in hours