ٍEvaluation of efficacy of combination of nebulized salbutamol with different concentration of saline ( normal saline 0/9%, hypertonic saline 3%, hypertonic saline 5%) in infant with bronchiolitis whom admitted in ali ebne abitaleb hospital of Zahedan, Iran.
Design: randomized, double blind, without control with blacebo, unicentral, stage 2 of clinical trial on infant with bronchiolitis whom admitted in hospital( age 4 weeks upto 24 months) and requier oxygen therapy.
Inclusion criteria: age less than 2 year old; history of recent upper respiratory viral infection which caused wheez and crakle in ascultation; CBSS 4-8 in admit.
Exclusion criteria: age less than 1 month or more than 2 years old; history of recurrent attack of wheez; sever neurologic disorder; consolidation in Chest x ray; immune deficiency; congenital heart disease; history of prematurity(gestational age less than 34 weeks); birth weight less than 2500 gr; sturation of oxygen less than 85% in room; CBSS less than 4 or more than 8; unstable hemodynamic(heart rate more than 200 per minute,blood pressure 2 standard deviation more or less than normal range for age and sex ,respiratory rate more than 70 per minute). Sample size:180; infants who have inclusion criteria and their respiratory rate is between 30-60(moderate group)with method of random number table devided in 3 groups, each group has 60 person.group 1 receive 5 ml normal saline 0/9 % and 0/15 mg/kg nebulized salbutamol, group 2 receive 5 ml hypertonic saline 3% and 0/15 mg/kg nebulized salbutamol, group 3 receive 5 ml hypertonic saline 5 % and 0/15 mg/kg nebulized saline, then clinical features, oxygen saturation, respiratory rate, heart rate, intercostal retraction, dyspnea and wheez evaluated pretreatment and each 20 minutes after treatment upto 3 times.