A comparative study of effectiveness and ineffectiveness of the nasal cannula with high pressure and continuous positive airway pressure through the nose for the treatment of premature infants with respiratory distress syndrome

This study will done with aim to investigate the effectiveness of the nasal cannula with high pressure and continuous positive airway pressure through the nose for the treatment of premature infants with respiratory distress syndrome. This study is not-blinded clinical trial. The study population will included all premature infants with less than 37 weeks gestational age with respiratory distress syndrome, hospitalized in Imam Reza Hospital in Kermanshah city that require surfactant injection in Insure way, that the number of 200 subjects are selected and randomly are assigned to experimental and control groups. In the first group after the injection of the surfactant and Extube, Placed under respiratory support with nasal (CPAP) and in the second group respiratory support is established using the oxygen hot and humid high flow through nasal cannula (HFNC). In the first group initiation of treatment is with 4 ml of water and Fio2 40% and in the second group Blender and nasal cannula devices with an inner diameter of 2 mm is used for administering oxygen . Then in both groups, the duration of treatment with nasal or nasal cannula, need for mechanical ventilation, need to prescribe another dose of surfactant, damage to the nasal septum, intracerebral bleeding, compared with each other during and end of the study. Inclusion criteria: premature infants under 37 weeks and over 24 weeks; respiratory distress syndrome; written informed consent of the parents Exclusion criteria: Apgar score of fifth minute less than 5; there are syndromes or major congenital anomalies; congenital heart disease, mother Radiography and chorioamnionitis

Vice chancellor for research, Kermanshah University of Medical Sciences