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The effects of aerobic training and response to single session exhaustion exercise on some antioxidant indicators of salivary and serum in young non-active men

Protocol summary

Summary
The purpose of the present study is to investigate effects of aerobic training and response to single session exhaustion exercise on some antioxidant indicators salivary and serum in young non-active men. Thirty healthy men in a randomized design, will allocate equally into two homogeneous group: training group (N = 15) or control group (N = 15). Subjects of training group will participate in 8 week aerobic training (3 session per week). After training period, all subjects (any groups) will participate in single session exhaustion exercise protocol on the treadmill (Bruce test). In both groups, physical fitness index (VO2max), body composition (BMI, body Fat percent), blood lipid profile, oxidative stress (salivary and serum malondialdehyde, total antioxidant capacity, glutathione peroxidase, superoxide dismutase, catalase and uric acid), and inflammatory indicator (salivary and serum C-reactive protein: CRP) will determine in before and after training period and also, after exhaustion exercise protocol.

General information

Acronym
IRCT registration information
IRCT registration number: IRCT2016042214371N2
Registration date: 2016-05-14, 1395/02/25
Registration timing: retrospective

Last update:
Update count: 0
Registration date
2016-05-14, 1395/02/25
Registrant information
Name
Vahid Sari-Sarraf
Name of organization / entity
University of Tabriz
Country
Iran (Islamic Republic of)
Phone
+98 41 3339 3254
Email address
sarraf@tabrizu.ac.ir
Recruitment status
Recruitment complete
Funding source
Vice chancellor for research, Tabriz University
Expected recruitment start date
2016-01-05, 1394/10/15
Expected recruitment end date
2016-03-17, 1394/12/27
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
The effects of aerobic training and response to single session exhaustion exercise on some antioxidant indicators of salivary and serum in young non-active men
Public title
Exercise-induced oxidative stress
Purpose
Basic scienece
Inclusion/Exclusion criteria
Inclusion criteria: Healthy male؛ Non-athlete؛ Non-Smoker؛Informed consent؛ without any inflammatory or oxidative supplement ingestion during 6 months prior to the study, Exclusion criteria: chronic diseases؛ injuries.
Age
From 18 years old to 21 years old
Gender
Male
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size: 30
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Not blinded
Blinding description
Placebo
Not used
Assignment
Parallel
Other design features
Randomization: By random numbers

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethics committee of Tabriz University of Medical Sciences
Street address
Golgasht street, Daneshgah street, Tabriz university of medical sciences Tabriz
City
Tabriz
Postal code
Approval date
2016-01-18, 1394/10/28
Ethics committee reference number
TBZMED.REC.1394.977

Health conditions studied

1

Description of health condition studied
oxidative stress
ICD-10 code
Z10.3
ICD-10 code description
Routine general health check-up of other defined subpopulations

Primary outcomes

1

Description
Total antioxidant capacity (TAC)
Timepoint
Before and after the initiation of the intervention (training), after one session acute aerobic exercise
Method of measurement
by ABTs Method.

2

Description
Malondialdehyde (MDA)
Timepoint
Before and after the initiation of the intervention (training), after one session acute aerobic exercise
Method of measurement
by thiobarbituric acid reactive substance (TBARS) and spectrophotometer

3

Description
Superoxide dismutase
Timepoint
Before and after the initiation of the intervention (training), after one session acute aerobic exercise
Method of measurement
Specific kit

4

Description
Catalse
Timepoint
Before and after the initiation of the intervention (training), after one session acute aerobic exercise
Method of measurement
by spectrophotometeric

5

Description
Glutathione peroxidase
Timepoint
Before and after the initiation of the intervention (training), after one session acute aerobic exercise
Method of measurement
Specific kit

6

Description
Uric cid
Timepoint
Before and after the initiation of the intervention (training), after one session acute aerobic exercise
Method of measurement
Specific kit

Secondary outcomes

1

Description
Lipid profile
Timepoint
Before and after the initiation of the intervention (training), after one session acute aerobic exercise
Method of measurement
by specific kits

Intervention groups

1

Description
Intervention group 1: 8 week aerobic exercise training, 3 session per day and single session exhaustion exercise
Category
Other

2

Description
Control group: single session exhaustion exercise
Category
Other

Recruitment centers

1

Recruitment center
Name of recruitment center
University of Tabriz
Full name of responsible person
Vahid Sari-Sarraf
Street address
Faculty of Physical Education & Sports Sciences,University of Tabriz, 29 Bahman Ave, Tabriz, Iran.
City
Tabriz

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Vice Chancellor for research of Tabriz University
Full name of responsible person
Dr Mohammad Moghaddam Vahed
Street address
University of Tabriz, 29 Bahman Ave, Tabriz, Iran.
City
Tabriz
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Vice Chancellor for research of Tabriz University
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty

Person responsible for general inquiries

Contact
Name of organization / entity
University of Tabriz
Full name of responsible person
Hamidreza Zolfi
Position
Phd Candidate of Exercise Physiology
Other areas of specialty/work
Street address
Faculty of physical education & sports sciences, University of Tabriz, Tabriz, Iran.
City
Tabriz
Postal code
Phone
+98 41 3339 3394
Fax
Email
hzolfi@tabrizu.ac.ir; hamidreza.zolfi@yahoo.com
Web page address

Person responsible for scientific inquiries

Contact
Name of organization / entity
University of Tabriz
Full name of responsible person
Dr Vahid Sari-Sarraf
Position
PhD in Exercise Physiology
Other areas of specialty/work
Street address
Faculty of physical education & sports sciences, University of Tabriz, Tabriz, Iran.
City
Tabriz
Postal code
Phone
+98 41 3339 3394
Fax
Email
vsarisarraf@yahoo.com; sarraf@tabrizu.ac.ir
Web page address

Person responsible for updating data

Contact
Name of organization / entity
University of Tabriz
Full name of responsible person
Hamid Reza Zolfi
Position
PhD Candidate of Exercise Physiology
Other areas of specialty/work
Street address
City
Postal code
Phone
00
Fax
Email
hzolfi@tabrizu.ac.ir
Web page address

Sharing plan

Deidentified Individual Participant Data Set (IPD)
empty
Study Protocol
empty
Statistical Analysis Plan
empty
Informed Consent Form
empty
Clinical Study Report
empty
Analytic Code
empty
Data Dictionary
empty
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