The objective of this single blind, placebo-controlled, randomized intervention trial is to determine the effects of dietary 600 mg/day gamma oryzanol supplementation during a 9-week resistance training program on altering lipid profile, anabolic/catabolic hormones, circulating binding proteins and anthropometric measures of young males during resistance training. Thirty two (32) eligible males with no continuous resistance training experience during six months before the study participation, with age 18-24 years were selected for the study and were randomized into two groups (either 600 mg of gamma oryzanol or lactose in the form of capsules). Prior to the study commencement, subjects’ squat 1 Repetition Maximum (1RM) was determined by means of 1RM strength tests on the regular leg curl and bench press machine, which was repeated on the last day of study. The main inclusion criteria were including having no previous continuous resistance training (as having resistance training for at least 20 minutes 2 to 3 times per week without stopping) during last 6 months before the study commencement; being males and age between 18-30. The main exclusion criteria consisted of: A history of cardiovascular disease; Lactose intolerance; Diabetes mellitus; Cancer; Hypertension; Chronic obstructive pulmonary disease; Psychiatric disease; Any other serious life-threatening illness that required regular medical treatment; Alcohol intake of 15 drinks or more per week or at least 30 g/d; <4d/week of recommended resistance exercise; <80% of provided supplement or placebo capsules; Smokers, or tobacco product consumers; Taking any weight lose drug or participating in any weight loss program or changing their diets for example vegetarian diet; Anti-inflammatory drugs, hormones supplements or any other supplements before (for a minimum of six months) or during the study period; Concurrent participation in other physical or exercise modalities. The intervention under study was supervised resistance training was performed four times a week, performing three sets (consisting of 6–12 repetitions) per exercise with three minutes rest, for a period of 9 weeks for each participant, accompanied with the consumption of supplement or placebo. At the study commencement in two times, before and after the acute resistance exercise, and at the end of the 9-week and 24 hours after the last resistance exercise performance, blood sampling were taken following 10-12 hour fast. Also, anthropomorphic measurements and physical performance were obtained before and after accomplishment of the study.