Effect of vitamin D supplementation on serum 25-hydroxyvitamin D levels, inflammatory biomarkers and total antioxidant capacity in different types of vitamin D receptor polymorphisms in breast cancer women

This study has been designed to evaluate the Effect of vitamin D supplementation on serum 25-hydroxyvitamin D levels, biomarkers of inflammation and total antioxidant capacity in different types of vitamin D receptor polymorphisms in breast cancer women. This study will be done as a double blind controlled randomized trial with a period of 8 weeks. Forty six subjects with cancer will be selected from Ahvaz Shafa Hospital. Inclusion Criteria are included all women who were diagnosed with stage ɪ breast cancer; age>20; 23< BMI<30; not consuming any kinds of vitamin D supplements during last 3 months. Exclusion criteria are included a history of any types of cancer; people with chronic diarrhea and malabsorption; non-Iranian races. The subjects will be divided into 2 groups based on randomized block design. Group 1 will receive 50000 IU of vitamin D3 per week, group 2 will receive placebo per week. Serum levels of TNF-α, TGF-β, TAC and 25 (OH) D will be determine by taking blood samples at the baseline and at the end of the intervention. VDR gene polymorphisms (FOK1, Bsml1, Taq and Apa1) will be determined by SSP-PCR techniques. Anthropometric measurements (height, weight and waist circumferences) will be measured at the baseline and after 8 weeks of the intervention.

Ahvaz Jundishapur University of Medical Sciences