Protocol summary

Summary
study purpose:comparing the efficacy of IV methyprednisolone plus oral prednisolone therapy with IV methyprednisolone therapy alone in the treatment of acute demyelinating optic neuritis study design:randomized,double blind,control with placebo,single central,stage 2 of trial, inclusion criteria:patient 15 to 50 years old reffered with opti neuritis" that their visual acuity decreased above 50%. exclusion criteria:side effect such as gastrointestinal bleeding...during usage of methyprednisolone puls and oral prednisolone" patients with diabets sample number:60 intervention: oral prednisolone usage inintervention group and placobo in control group. intervention time:10 days. study effect:recovery of visual acuity and color vision

General information

Acronym
IRCT registration information
IRCT registration number: IRCT2015102724734N1
Registration date: 2016-04-18, 1395/01/30
Registration timing: retrospective

Last update:
Update count: 0
Registration date
2016-04-18, 1395/01/30
Registrant information
Name
Adel Nejati khoshkbejari
Name of organization / entity
Ahvaz University Of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 61 3375 4564
Email address
nejati.a@ajums.ac.ir
Recruitment status
Recruitment complete
Funding source
investigator
Expected recruitment start date
2015-11-20, 1394/08/29
Expected recruitment end date
2016-02-17, 1394/11/28
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
comparing the efficacy of IV methyprednisolone plus oral prednisolone therapy with IV methyprednisolone therapy alone in the treatment of acute demyelinating optic neuritis
Public title
prednisolone effect in optic neutitis
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:patient 15 to 50 years old reffered with optic neuritis" that their visual acuity decreased above 50% Exclusion criteria:side effect such as gastrointestinal bleeding ,...during usage of methyprednisolone puls and oral prednisolone" patients with diabet
Age
From 15 years old to 50 years old
Gender
Both
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size: 60
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Double blinded
Blinding description
Placebo
Used
Assignment
Parallel
Other design features
randomized desin:blocking

Secondary Ids

1

Registry name
no registry anywhere
Secondary trial Id
-
Registration date
empty

2

Registry name
در جایی ثبت نشده است
Secondary trial Id
-
Registration date
empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethics committee of Ahvaz Jundishapur university of Medical Sciences
Street address
Central organization,Ahvaz Jundishapur university of Medical Sciences ,golestan bolvar,Ahvaz,khoozestan
City
ahvaz
Postal code
Approval date
2015-05-30, 1394/03/09
Ethics committee reference number
ir.ajums.rec.1394.179

Health conditions studied

1

Description of health condition studied
optic neuritis
ICD-10 code
g35-g37
ICD-10 code description
demyelinating diseases of the central nervous system

Primary outcomes

1

Description
visual acuity
Timepoint
before.first day after end of intervention, 1month.3months afte intervention
Method of measurement
snellen chart

Secondary outcomes

1

Description
color vision
Timepoint
before,first day after end of intervention ,1month,3months after intervention
Method of measurement
farnsworth d15

Intervention groups

1

Description
intervention group:Tab prednisolone 50 mg po for 10 days,Made by:Abureihan pharmacy
Category
Treatment - Drugs

2

Description
control group:Tab placebo po daily for 10 days,Made by: Jondishapur Ahvaz University of Pharmacy Sciences
Category
Placebo

Recruitment centers

1

Recruitment center
Name of recruitment center
Golestan hospital
Full name of responsible person
Seyed Ehsan Mohammadyani nejad-assistant professor of neurology
Street address
Khoozestan-Ahvaz-Golestan-Golestan hospital-Neurology ward
City
ahvaz

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
vice chancellor for research,Ahvaz jundishapur University of Medical Sciences
Full name of responsible person
nader saki
Street address
Ahvaz jundishapur University of Medical Sciences, central organization,Golestan bolvar, Ahvaz, khoozestan
City
ahvaz
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
vice chancellor for research,Ahvaz jundishapur University of Medical Sciences
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty

Person responsible for general inquiries

Contact
Name of organization / entity
Ahvaz University Of Medical Sciences
Full name of responsible person
Seyed Ehsan Mohammad Yani Nejad
Position
Assistant Professor of Neurology
Other areas of specialty/work
Street address
Golestan Hospital,Neurology ward,Ahvaz
City
Ahvaz
Postal code
Phone
+98 61 3374 3012
Fax
+98 61 3374 3012
Email
ehsanneuro@Gmail.com
Web page address

Person responsible for scientific inquiries

Contact
Name of organization / entity
Ahvaz University Of Medical Sciences
Full name of responsible person
Seyed Ehsan Mohammad Yani Nejad
Position
Assistant proffesor of neurology
Other areas of specialty/work
Street address
Golestan,golestan hospital,neurology ward
City
Ahvaz
Postal code
Phone
+98 61 3374 3012
Fax
+98 61 3374 3012
Email
ehsanneuro@Gmail.com
Web page address

Person responsible for updating data

Contact
Name of organization / entity
Ahvaz University Of Medical Sciences
Full name of responsible person
Adel Nejati khoshkbejari
Position
Assistant of neurology
Other areas of specialty/work
Street address
Khoozestan,Ahvaz,Golestan hospital
City
Ahvaz
Postal code
Phone
+98 613743702
Fax
+98 613743702
Email
nejati.a@ajums.ac.ir
Web page address

Sharing plan

Deidentified Individual Participant Data Set (IPD)
empty
Study Protocol
empty
Statistical Analysis Plan
empty
Informed Consent Form
empty
Clinical Study Report
empty
Analytic Code
empty
Data Dictionary
empty
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