Efficacy of Oral Amiodarone Administration on Prevention of Cardiac Arrhythmia Following Open Heart Surgery, aRandomized Clinical trial Study

This study was a randomized, double blind clinical trial. 400 patients with open heart surgery candidates were randomly divided into two groups, with and without (control) amiodarone. Finally, the prevalence of cardiac arrhythmias after surgery until the patient's stay in the intensive care unit is recorded in the questionnaires.

A concealed, randomized, blinded, sham controlled clinical trial with a parallel group design of 501 patients, enrolled between April 2016 and March 2018, and followed for one year

In the intervention group, 200 mg of amiodarone was given orally twice a day until the patient was cleared. Patients in the control group received placebo (vitamin B1). The frequency and duration of use of placebo in the control group were completely similar to the oral administration of amiodarone in the intervention group. Electrocardiogram monitoring was conducted continuously and monitored.

Age over 18 years, [pen heart surgery, Sinus rhythm and normal function of liver, renal system , pulmonary system and thyroid. History of atrial and ventricular arrhythmia and cardiac blocks, patient's need for Pace, anti-arrhythmic therapy, Age over 80 years, pregnant patients

In the intervention group, 200 mg of amiodarone was given orally twice a day until the patient was cleared. Patients in the control group received placebo (vitamin B1). The frequency and duration of use of placebo in the control group were completely similar to the oral administration of amiodarone in the intervention group.

Incidence of types of arrhythmia, duration of admission to ICU, hospitalization time and side effects of amiodarone

Mazandaran University of Medical Scienses

Random method and description of each method: simple randomization After determining the size of the sample, 400 people, 200 in the control group and 200 in the intervention group were considered. By co-ordinating medical records, this number was considered average for the duration of the appointment, and then the list of individuals was determined. The list was prepared based on the patients' turn-by-turn and then, using the random numbers table, the numbers of the control and intervention group were determined and compared to the coordination for the next steps.

Patients and therapists are not aware of the type of drug present in the pills (amiodarone or vitamin B1), and only the researcher knows about the code inserted (code A or code B) on the pill pack.