The purpose of this study is to evaluate the effects of three modes of training on serum level of irisin, myostatin, blood lipids, glucose homeostasis, physical fitness and body composition after 8 weeks of training in young girls. Inclusions criteria consist of 20-35 years normal and overweight inactivate girls and exclusion criteria will be include of absence for four sessions. In line with this, through the students of a faculty of Islamic Azad University of Rasht, 40 girls will be select and randomly assign into four groups and each group consist of 10 persons including: control, aerobic training, resistance training and concurrent training (aerobic-resistance). Subjects in the all training groups do exercise 3 times per week according to recommendations of American college of sport medicine. Fasting blood sample will be taken before and 24 hour after last training session, to evaluate Serum level of irisin, myostatin, blood lipids and glucose homeostasis concentration. Also, Subject’s physical fitness and body composition will be measured before and after the end of training period. The study duration will be 8 weeks and it seems that doing an aerobic, resistance or concurrent training, all can be effective on circulating irisin and myostatin levels, but the effect size will be different in the various types of training.