Objective: To determine the effect of vitamin D in adolescents with polycystic ovary syndrome have vitamin D deficiency.
Design, Setting and conduct: Random; alternating block method; single-blind; two intervention and control groups.
Inclusion criteria: age 14 to 18 years old; people with impaired ovulation or anovulation for oligoovulation (oligo- and / or anovulation); 2 and 3 Hyperandrogenemia clinical hyperandrogenism or There polycystic ovarian morphology on ultrasound and they are deficient in vitamin D, and the study Azargoon et al(1) known as polycystic ovarian syndrome.
Exclusion criteria: people who do not have full consent to participate in this study; Those who did not use vitamin D to regular weekly; Those in the intervention of the symptoms of polycystic ovary syndrome drugs such as birth control pills, metformin, medroxyprogesterone and progesterone intramuscular injection except in the event of amenorrhea has 45 days from the previous cycle dose of 200 mg for the induction periods are used.
Intervention and main outcome measures: In the intervention group, weekly 50000 units of vitamin D and the control group, the placebo treatment in both groups 8 weeks will be (based on studies of Thomson et al. 2012); intervention, in the first day of bleeding, weekly and then monthly up to 8 weeks to two months continues. Methods of collecting data with demographic questions, blood pressure and check list data obtained from in vitro assays (FBS and fasting insulin, TG, HDL and LH, FSH, testosterone and 25 hydroxyvitamin D3) and clinical (hirsutism, acne, menstrual pattern) and ultrasound done.