Objectives: The aim of this study is to determine the Effects of Q10 supplementation on serum some biochemical variables in patients with type 2 diabetes.
Design: In this double blind study, a total number of 70 patients will be selected. They will be divided into two groups of intervention (coenzyme Q10) and control (placebo) by simple random sampling. They will be matched in age and BMI. The endocrinologist, pharmacy and the participants will be blinded to the study interventions.
Setting and conduct: The aim and procedures of the study will be conveyed to the participants and written informed consent will be obtain from each of them.
Major Inclusion and Exclusion criteria: Major inclusion criteria are Type 2 diabetic patients for more than 2 years and not consumption of vitamin and mineral supplements during the last three months. Major Exclusion criteria are changing in dosage of glucose lowering medications, physical activity and diet during the intervention.
Intervention: One group will receive coenzyme Q10 (one 100 mg capsule for 12 weeks) and the other group will receive placebo capsule containing cellulose acetate for the same dosage and period.
Main outcome measures (variables): Serum levels of glucose, hemoglobin A1c, insulin, cholesterol, triglyceride, HDL-C, LDL-C, hs-CRP, Q10, gamma glutamyl transferase, pseudo cholinesterase, bilirubin and ferritin will be measured at the beginning and at the end of the intervention.