Protocol summary

Summary
Objective: Effect of rehabilitation with and without non-invasive ventilation on lung function and COPD assessment test particularly for patients admitted to Masih daneshvari hospital in autumn and winter 1395. Study design: Randomized, double-blind, placebo-controlled, single-center, phase two and three trials. Study population: all patients with chronic obstructive pulmonary disease referring to Masih daneshvari hospital in the fall and winter of 1395 Inclusion criteria: (1) identifying chronic obstructive pulmonary disease, (2) the satisfaction of participating in the study, (3) the Consciousness to complete the tests Exclusion criteria: (1) inability to carry out the rehabilitation, (2) the occurrence of exacerbation or disease attack Sample Size: 50 Interventions include breathing exercises and physical therapy, pulmonary rehabilitation program (3 times a week 3 weeks) and concurrent use of non-invasive ventilation Implications of the study: the distance walked in 6-minute walk test, measurement values: venous blood gas analysis, pulmonary function tests, Chronic Obstructive Pulmonary Diseases assessment questionnaire

General information

Acronym
IRCT registration information
IRCT registration number: IRCT2016102927929N3
Registration date: 2017-02-14, 1395/11/26
Registration timing: registered_while_recruiting

Last update:
Update count: 0
Registration date
2017-02-14, 1395/11/26
Registrant information
Name
Atefeh Fakharian
Name of organization / entity
National research institute of tuberculosis and lung diseases
Country
Iran (Islamic Republic of)
Phone
+98 21 2712 2541
Email address
afakharian@sbmu.ac.ir
Recruitment status
Recruitment complete
Funding source
Shahid Beheshti University of Medical Sciences
Expected recruitment start date
2016-09-22, 1395/07/01
Expected recruitment end date
2017-03-18, 1395/12/28
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Effect of rehabilitation with and without Non Invasive Ventilation on change in pulmonary function and CAT scores of COPD patients at Masih Daneshvari Hospital
Public title
Effect of rehabilitation with and without Non Invasive Ventilation among COPD subjects
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria: identifying chronic obstructive pulmonary disease; the satisfaction of participating in the study; The Consciousness of subjects Exclusion criteria: inability to carry out rehabilitation; the occurrence of exacerbation or disease attack
Age
No age limit
Gender
Both
Phase
2-3
Groups that have been masked
No information
Sample size
Target sample size: 50
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Double blinded
Blinding description
Placebo
Used
Assignment
Parallel
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Vice-Chancellor in Research Affairs of Shahid Beheshti University of Medical Sciences
Street address
7th Floor, Bldg No.2 , Arabi Ave, Daneshjoo Blvd, Velenjak,
City
Tehran
Postal code
Approval date
2016-04-14, 1395/01/26
Ethics committee reference number
IR.SBMU.MSP.REC.1395.235

Health conditions studied

1

Description of health condition studied
Chronic obstructive pulmonary disease
ICD-10 code
J44.9
ICD-10 code description
Chronic obstructive pulmonary disease, unspecified

Primary outcomes

1

Description
Distance covered during 6 minutes
Timepoint
Before and immediately after intervention
Method of measurement
six minute walk test

2

Description
COPD assessment test score
Timepoint
Before and immediately after intervention
Method of measurement
COPD assessment test questionnaire

Secondary outcomes

1

Description
Forced expiatory volume in 1st second
Timepoint
Before and immediately after intervention
Method of measurement
spirometry

2

Description
pressure of CO2
Timepoint
Before and immediately after intervention
Method of measurement
Venus blood gas

Intervention groups

1

Description
Control group: 3 session/week for 3 weeks of rehabilitation including respiratory exercise and exercise therapy and Non invasive ventilation mask while the device is off.
Category
Treatment - Devices

2

Description
Intervention group: 3 sessions/ week for 3 weeks of rehabilitation including respiratory exercise and exercise therapy and Non Invasive Ventilation while the device is on.
Category
Treatment - Devices

Recruitment centers

1

Recruitment center
Name of recruitment center
Masih daneshvari hospital
Full name of responsible person
Marzie Mobininezhad
Street address
Darabad Avenue, Shahid Bahonar roundabout
City
Tehran

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Vice Chancellor for research ofShahid Beheshti University of Medical Sciences
Full name of responsible person
Afshin Zarghi
Street address
7th Floor, Bldg No.2 , Arabi Ave, Daneshjoo Blvd, Velenjak
City
Tehran
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Vice Chancellor for research ofShahid Beheshti University of Medical Sciences
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty

Person responsible for general inquiries

Contact
Name of organization / entity
Shahid Beheshti University of Medical Sciences
Full name of responsible person
Dr. Atefeh Fakharian
Position
pulmonologist
Other areas of specialty/work
Street address
Masih Daneshvari Hospital, Darabad Avenue, Shahid Bahonar roundabout,
City
Tehran
Postal code
Phone
+98 21 2610 5050
Fax
Email
fakharian_2005@yahoo.com
Web page address

Person responsible for scientific inquiries

Contact
Name of organization / entity
Shahid Beheshti University of Medical Sciences
Full name of responsible person
Atefeh Fakharian
Position
pulmonologist
Other areas of specialty/work
Street address
Masih Daneshvari Hospital, Darabad Avenue, Shahid Bahonar roundabout,
City
Tehran
Postal code
Phone
+98 21 2610 5050
Fax
Email
fakharian_2005@yahoo.com
Web page address

Person responsible for updating data

Contact
Name of organization / entity
Shahid Beheshti University of Medical Sciences
Full name of responsible person
Marzie Mobininezhad
Position
Resident of Internal medicine
Other areas of specialty/work
Street address
Masih Daneshvari Hospital, Darabad Avenue, Shahid Bahonar roundabout
City
Tehran
Postal code
Phone
+98 21 2712 2035
Fax
Email
marzie1984mobini@gmail.com
Web page address

Sharing plan

Deidentified Individual Participant Data Set (IPD)
empty
Study Protocol
empty
Statistical Analysis Plan
empty
Informed Consent Form
empty
Clinical Study Report
empty
Analytic Code
empty
Data Dictionary
empty
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