Comparison the effectiveness of diazepam and phenobarbital for prevention of recurrent seizure In early stages of febrile convalsion in children 6 month to 5 years

The aim of this study is to compare the effectiveness of 3 interventions for prevention of recurrence in early stages of febrile seizures in children under 5 years. This study will determine whether these interventions or no intervention are different during the course of the disease? In addition, the mentioned interventions are accompanied with what kind of side effects. In this study all of the patients who are qualified to include in the research will be included gradually in the study. In based on block randomization. Group 1: the patients who won t receive any drug of seizure. Group 2: the patients will receive phenobarbital stat 10 mg/kg IM at the beginning of the admit. Group 3: the patients will receive phenobarbital stat 10mg/kg IM at the beginning of the admit and then 2.5 mg/kg/dose IM every 12 hours and this process will be followed by receiving tab phenobarbital with the same dose after the beginning of oral nutrition until cut fever. Group 4: the patients will receive tab diazepam 0/3 mg/kg in every 8 hours and this process will be continued until cut fever. If one of the mentioned group will strike recurrent seizure during the period of admit in the hospital regardless of the above groups they will receive amp phenobarbital 10 mg/kg IM STAT and 2/5 mg/kg/dose every 12 hours and this process will be followed by receiving tab phenobarbital with the same dose after the beginning of oral nutrition. the patient information will be recorded as recurrent seizure.all of the patients will be checked for the reason of fever.the LP will be accomplished according to circumstance and regarding to the available indication about the reason of the fever.for all of the patients if the temperature of the axillary will be more than 37/5 C. According to circumstance the syrup acetaminophen 10-15 mg/kg oral will be prescribed .regarding to the patient conditions the patient will be requested to do routine tests.in the cases such as complex febrile seizure or the history of developmental delay or neurological exam the patients are requested to do brain CT scan or brain MRI. All of the information including of the personal information family history the seizure caracteristic and recurrency of seizure will be recorded in the information form and the results will be evaluated using SPSS 16 software.

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