Therapeutic effect of Nasal high frequency ventilation(NHFV) versus nasal continuous positive airway pressure(NCPAP) for respiratory distress syndrome in newborn with birth with more than 1000 gram and more than 30 week of gestational age

Premature infants with respiratory distress syndrome (RDS) usually require respiratory support. Due to the complications of intubation and mechanical ventilation, in the last decade, attempts have been made to use non-invasive methods in management of these patients. One of the most commonly used non-invasive methods is nasal CPAP. However, some neonate with this therapeutic approach also developed respiratory failure and they need more respiratory support. So far, the beneficial effects of high frequency ventilators have been shown in management of RDS, However, its effect on the nasal method has been less studied. In this study we evaluate the efficacy of nasal high frequency ventilation (NHFV) in reducing the duration of respiratory distress compared with nasal continuous positive airway pressure (NCPAP) in RDS. In this randomized-prospective study, 62 infants with a gestational age ≥ 30 weeks and birth weight ≥ 1000 g with RDS and spontaneous breathing since birth will randomized to either NHFV (n = 31) or NCPAP (n = 31). Infant were excluded if there was any of the following cases: major congenital anomalies; asphyxia and cyanotic congenital heart disease. The primary outcome is the reduction of the duration of respiratory distress. Secondary outcome are the duration and level of oxygen supplementation, the incidence of complications such as pneumothorax, necrotizing enter colitis, sepsis and respiratory failure requiring intubation.

Isfahan University of Medical Sciences, Isfahan, Iran