Main objectives of the project: Determination of complementary effects of nanocurcumin and ubiquinone on serum levels of homocysteine, calcitonin gene-related peptide, oxidative stress profile, gene expression, and activity of some antioxidant enzymes in migraine patients. Design Study: Randomized, double-blind, placebo-controlled. The study population: All patients with migraine referring to the Neurology Clinic of Imam Khomeini Hospital in Tehran. Inclusion criteria: 20 to 45 years old; Patients with episodic migraine; Migraine Diagnosis by International Headache Society Criteria as Applied by a Neurologist; No nutritional supplement or professional sports activities four weeks before intervention; People who are willing to cooperate voluntarily. Exclusion criteria: Kidney disease; liver disease; pancreatitis; diabetes; cancer; thyroid disorders and inflammatory diseases based on medical history; Malnutrition (body mass index less than 18.5) and obesity (body mass index greater than 30); Vitamin supplementation during the three months before intervention; Pregnancy; Alcohol consumption over the past six months; smoking; Patients with history of cardiovascular disease; Taking anti-inflammatory drugs or supplements such as ubiquinone and curcumin; Allergic reaction to the ubiquinone and/or Curcumin supplement; Lack of patient collaboration; Any significant changes in diet and routine life. Sample size: 80. Intervention: Patients will be divided into four groups, according to stratified randomization method: 1.The group receiving ubiquinone (sauna medicine in Parseh, Iran) (100 mg three times daily) and nanocorcomin (Sina Kurkamin, Iran) (80 mg per day). 2.Nano-curcumin supplement and ubiquinone placebo (Minoo Co., Iran). 3.ubiquinone Supplement and Curcumin Placebo (Minoo Co., Iran). 4.The control group consisted of patients receiving ubiquinone placebo and curcumin placebo for two months. Primary outcome measure: Number of headache attacks, duration of headache and headache severity. Secondary outcome measure: Laboratory parameters including serum levels of Calcitonin gene-related peptide, homocysteine, oxidative stress profile, catalase, superoxide dismutase, glutathione peroxidase activity and gene expression in PBMC.