Determining the effect of vitamin D supplements on oxidative stress markers and weaning from mechanical Ventilatory Traumatic patients admitted to intensive acre unit
Design
In this randomized clinical trial, 72 patients, 18-65 years old, undergoing mechanical ventilation in the intensive care unit, were randomly divided into two intervention groups and one control group.
Settings and conduct
This single-blind study will be performed on patients undergoing mechanical ventilation in the intensive care unit of Urmia Imam Khomeini Hospital. Patients will be randomly assigned to 3 groups (the first group will be vitamin D, the second group will be vitamin D and the third control group). The study will be single-blind so that patients will not be informed about which groups will be assigned.
Participants/Inclusion and exclusion criteria
Inclusion criteria: Patients aged 18-65 years undergoing mechanical ventilation with a serum vitamin D level of between 10-30 ng/ml.
Exclusion criteria: patients with chronic and acute renal failure, hemodialysis or peritoneal dialysis and GCS less than 9.
Intervention groups
Patients in the intervention groups will receive 50000 units of vitamin D for 6 consecutive days or vitamin D 300,000 units in muscle once. The control group will not receive any intervention.
Assessment of the effect of Vit D supplementation on oxidative stress markers and weaning from mechanical Ventilatory Traumatic patients
Public title
Assessment of the effect of Vit D supplementation in mechanical Ventilatory Traumatic patients
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
All mechanical Ventilatory Traumatic patients admitted to intensive acre unit
The age group 18-65 years
Vit D serum level between 10-3 ng/ml
Minimum length of stay 7 days in ICU
Exclusion criteria:
Patients with chronic and acute renal failure
Patients under hemodialysis or peritoneal dialysis
GCS<9
Age
From 18 years old to 65 years old
Gender
Both
Phase
3
Groups that have been masked
Participant
Sample size
Target sample size:
72
More than 1 sample in each individual
Number of samples in each individual:
1
Each participant will provide a sample for study.
Randomization (investigator's opinion)
Randomized
Randomization description
Using statistical software, patients will be randomly assigned to the intervention groups and control group.
Blinding (investigator's opinion)
Single blinded
Blinding description
this study will be carried out single blind so that the patient is unaware.
Placebo
Not used
Assignment
Parallel
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Ethics committee of Urmia University of Medical Sciences