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Study aim
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Determination of vitamin D supplementation on inflammatory markers (IL-10, IL-12), antioxidant (TAC), and physique and mood syndrome of students with premenstrual syndrome (PMS) and vitamin D deficiency
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Design
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Double-blind randomized clinical trial with parallel control group
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Settings and conduct
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The subjects from among 18-25 year-old female students with premenstrual syndrome and vitamin D deficiency in Isfahan University of medical sciences who have criteria for entering the study will be selected through multistage random cluster sampling
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Participants/Inclusion and exclusion criteria
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Aged 18-25 years, having normal BMI, single, serum vitamin D levels of 10-30 ng / ml, regular menstrual cycle with intervals of 21-35 days, lack of depression and anxiety, lack of diseases Acute and chronic, lack of iron deficiency anemia (anemia), lack of exercise on a regular basis, no use of combined tablets containing estrogens and progesterone , Lack of vitamin D supplementation in the past 3 months, the student does not start or finish the term in the semester
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Intervention groups
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During the four menstrual cycles, every two weeks, the intervention group receives an oral supplement of 50,000 units of vitamin D and the control group receiving a placebo that looks like vitamin D supplementation. People are asked to complete the PMS daily registration form during the last 2 additional cycles of supplemental supplementation.
The amount of vitamin D intake will be collected through the Frequency Frequency Questionnaire. The levels of vitamin D, inflammatory markers and antioxidant in luteal phase and anthropometric information (weight, height, BMI and waist circumference) will be measured before and after intervention.
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Main outcome variables
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Levels of Interleukin 10 and 12 and total antioxidant capacity; Physical and psychological Symptoms of syndrome