Assessing the effect of vitamin D on the CD4 count and some blood indices in Human Immunodeficiency Virus (HIV) patients

Assessing the effect of vitamin D on the CD4 count and some blood indices in HIV patients

Randomised with a parallel group design of 66 patients in intervention and control group by simple random sampling

The data collecting was performed at Varamin Behavioral Counseling Center.The information collecting method was conducted by interviewing and filling out the questionnaire. The last CD4 of these patients was measured during their periodic evaluation every 3 months. CBC tests were performed for all patients at the same time as their CD4 levels were measured. a Perl of 50,000 units of vitamin D3 was orally administered per month to patients in the intervention group. three and six months after the intervention, the questionnaire was again filled up for the complete research samples and the tests contained therein.

The inclusion criteria are include non-pregnant women and men who had HIV infection, age older than 18 years, intervals of at least 6 months since the start of the last regimen, not taking vitamin supplements at least three months before the start of the study, no diseases and acute problems preventing intervention by taking vitamin D3 Exclusion criteria are include modifying the antiretroviral therapy during the study, getting pregnancy in female patients, the absence of referral patients for monthly supplementation of vitamin D3, people with sarcoidosis, hyperparathyroidism, kidney disease and histoplasmosis

Intervention group: People who in addition to receiving antiretroviral drug take a Perl of 50,000 units of vitamin D3 orally per month. control group: People who only receive antiretroviral drug.

Increased levels of vitamin D3 in patients؛ Increased number of CD4 and other blood factors

At first, by simple random sampling, the names of all people met the inclusion criteria were listed in the list of registered individuals at the specialist offices of the counseling center. After examining their files, their phone numbers and addresses were extracted. They were contacted and if they were enrolled to the study, if they were willing to cooperate and participate. Individuals were randomly entered the intervention and control groups. In this way, the cards with numbers 1 and 2 were prepared; the code of one was related to intervention as compared to the code of two for control group. These cards were placed in a thick envelope, and patients in the first stage of sampling, when they went to each, chose a card, and they were placed in the corresponding group.