Age 18 years and over, at least 3 months history of hemodialysis, verbal, mental and visual disability, antinociceptive dependence, pre-cannulation pain, no analgesics, Thymus Vulgaris and purslane 24 hours before hemodialysis, no ulceration Fistula, no liver disorders, asthma, allergy and dermatitis, no known allergy or allergy to Thymus Vulgaris and purslane, no alcohol and drugs, no history of mental illness and hospitalization, are the criteria for entry. Patient's unwillingness to continue research, occurrence of any adverse drug reaction or response during intervention, failure to perform cannulation In the first act and the need for repeated cannulation, death or migration patient Exclusion criteria are