Evaluation of the effectiveness of cold plasma radiation in the treatment of infected wounds diabetic foot and molecular mechanisms related

Determination of the Effect of Plasma Radiation on the Treatment of Diabetic Foot Infections and decrease of bacterial load and ulcer size

This is a double-blind clinical trial. Diabetic patients referred to diabetic clinics with 40 cases of diabetic foot ulcer infection are selected based on entry and exit criteria. After completing the informed consent form and the questionnaire, diagnostic tests are performed for all patients. Blood samples are taken from all patients for the following tests: FBS, HbA1c, Cr. , BUN, CBC, CRP, Chol, TG, LDL, HDL, ALT, AST, ALK Ph The standard measures are taken to treat the wounds of diabetic patients: 1) Normal saline wash and wound debridement 2) Appropriate antibiotic administration 3) Reduced wound pressure 4) Suitable dressing 5) Patient training 6) Patient's glycemic control. Sampling of wound secretions is performed to perform cytokine tests or angiogenesis factors before and during the third week. Then, in both groups, the wound of the scar tissue is wound in the standard method at regular intervals of the week.  A cold jet plasma rifle will be used as the source for the jet plasma with helium gas. The plasma is created in 1 day intervals and each time for 5 minutes on the wound will be directly exposed.

Diabetes Clinic - Diabetes Research Center

The criteria for entering the design are: 1) Grade 2 wounds according to Wagner and Texas classification and stage B 2; and 3) Wound type: Neuropathy, neuroiscaemia Exit criteria: 1) Pregnancy 2) Lactation 3) Cancer diagnosed and treated 4) Under 18 years of age 5) Dementia 6) Immunosuppressive drugs 7) Gangrene wounds 8) Ischemic ulcer 9) Non-cooperation

Diabetic Patients with infected foot ulcers

Reduce bacterial load and the size of the wound and Formation of granulation tissue

The first step in the random process is to create a random sequence. The second step after creating a random sequence is to hide the generated sequence. To use the random number table, we must first determine the number of the table to read. The second is to consider numbers for different groups (for example, pair numbers for intervention A and individual numbers for intervention B, then hand over one of the numbers and move in one of the directions predetermined and record the numbers We assign to different groups. Blocking is usually used to create a balance in the number of specimens assigned to each of the groups studied, for example, in blocks of 4 that have two allocations to the intervention group and two allocations to the control group Is taken.

Doctors and nurses, as well as the patient, are unaware of the grouping, and the only expert on plasma radiation is aware of this. Patients do not see the ulcer during plasma radiation

ethical