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Study aim
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The effect of brewed chicory leaf consumption on liver steatosis, enzymes, metabolic syndrome components, oxidative stress markers, C-reactive protein in patients with non-alcoholic fatty liver disease
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Design
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Clinical trial, control group, parallel groups, single blind, randomized with Stratified Block Randomization and sample size of 60 people, Phase 3 trial
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Settings and conduct
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The place of study is the Urmia Medical Clinic.
Liver enzymes, lipid profile test, FBS, blood pressure, and possible side effects will be measured at baseline, week 6 and end of study and liver ultrasound, c-reactive protein, insulin, oxidative stress index (TAC, SOD) will be measured at the beginning and end of the study. Both groups will follow same diet.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria included grade 2 and 3 non-alcoholic fatty liver disease, over 18 years, both sexes; Exclusion criteria included alcohol consumption, rheumatoid arthritis and other acute inflammatory diseases, NSAID, statins, phenytoin, karmabazepine, barbiturates, alpha-1 antitrypsin deficiency, heart failure, bone disease, Coeliac, vitamin, antioxidants, fiber and omega-3, anticoagulation and hepatotoxic drugs, hereditary hemochromatosis and Wilson's disease, renal disease, diabetes mellitus, hypothyroidism
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Intervention groups
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The intervention group will receive 15 grams of chicory leaf daily for 12 weeks, except for routine treatment by the gastroenterologist, and the control group will receive only the usual treatment.
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Main outcome variables
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ALT،AST،GGT،ALP، hs-CRP، Bilirubin total،SOD،TAC،CBC، Na, liver Steatosis, FBS, Alb, Ca, Creatinine, phosphorus, lipid profile, potassium