Survey the Effect of celery seed on serum levels of hepatic enzymes, lipid profile, glycemic parameters and hepatic steatosis degree in nonalcoholic fatty liver disease patients, with overweight and obesity

Effect of celery seed supplementation on serum levels of liver enzymes (AST, ALT), lipid profile (VLDL HDL, LDL, TG), glycemic index and degree of hepatic steatosis in obese and overweight non-alcoholic fatty liver patients

In this double-blind, single-center clinical trial study, 44 patients with nonalcoholic fatty liver were randomly divided into two groups of 22 intervention and control group. Randomization occurs by blocking.

This study is performed on people with non-alcoholic fatty liver referred to gastrointestinal clinic in Ahvaz. Researchers and patients will not be aware of how they are randomly assigned to groups (double blind). Before and after the study, liver enzymes and lipid profiles and fasting blood glucose and insulin levels and hs-CRP and anthropometric measurements were measured.

Overweight and obese patients (with BMI> 25) with nonalcoholic fatty liver (grade 1, 2) having ultrasound sheet with diagnosis of nonalcoholic fatty liver with radiologist and gastroenterologist approval

The intervention group received 4 capsules daily of 500 mg celery seed for 6 weeks. The control group received 4 placebo 500 mg starch capsules daily.

Fasting blood sugar, hepatic enzymes(ALT,AST), lipid profile (TG,Chol, HDL, VLDL), serum insulin, Insulin resistance index, Hs-CRP

44 subjects were divided into two groups of 22 intervention and control groups based on the block design method. In this way, an out-of-study third person who is familiar with health issues gives the supplement and placebo the same two codes as A and B. Subsequently, individuals are assigned AABB and BBAA. There are actually two 4-block blocks, each block having two A codes and two B codes. People are given codes in order to reach number 8, and repeat this number until they reach number 16. Then one of the blocks is repeated again to reach 20. Then the remaining two people receive a random code A or B code that reaches 22 people.

In this study, the researcher and the participants are kept blind, and the third person oversees the intervention and control groups outside the study.

Due to the financial support of this research project by Ahvaz Jundishapur University of Medical Sciences, the study data will not be allowed to be published after the intervention.