Effects of curcumin supplementation on some metabolic and clinical parameters in women with rheumatoid arthritis

Determining the effect of curcumin supplementation on some metabolic and clinical parameters in women with rheumatoid arthritis

Samples were selected using available methods and randomly assigned random blocks of 8 volumes to the study groups. A random sequence is generated using the STATA14 software. During the random assignment, individuals in the groups will be classified according to menopausal status, age and BMI variables

The aim of this study is the investigate the effects of curcumin supplementation on some metabolic and clinical parameters in women with rheumatoid arthritis that referred to Rheumatology Clinic of Imam Reza Hospital in Tabriz. 24-hour dietary recall questionnaire for 3 days, anthropometric indices , IPAQ, DAS28 will be completed for each individual. At the beginning and end of the intervention, 8 ml venous blood samples will be taken and kept at -70° until testing

include criteria: The age range of 20-70 years in women,Diagnosis of RA according to ACR, Moderate RA (disease activity score 1.5-3.2), No infectious disease at least two weeks before study, Body mass index less than 40 kilograms per square meters, willingness to participate in the study. exclude criteria: Pregnant or lactating women and those under hormone therapy or use of oral contraceptives, suffering from cardiovascular disease, liver and kidney failure and inflammatory disease, diabetes and hypertension, Changes in medications during the study, use of curcumin supplements and any antioxidant supplements in the last 2 months and during the study, weight loss diet, smoking.

group 1 receiving curcumin (1 capsule 500 mg), group 2 placebo group (1 capsule 500 mg placebo)

serum level of lipid profile, glycemic, hs-CRP, ESR, visfatin and Disease Activity Score28 (DAS28)

Samples were selected using available methods and randomly assigned random blocks of 8 volumes to the study groups.A random sequence is generated using the STATA14 software.During the random assignment, individuals in the groups will be classified according to menopausal status ,age and BMI variables.

The placebo and supplement will be packed in the same number in similar packages. The method of blindness will be that the supplements and placebo will be delivered to the participants by someone other than the researcher, and the researcher will remain unaware until the end of the study.