Comparison of Anjebar Syrup and Mefenamic Acid on Abnormal Uterine Bleeding

The aim of this study was to compare the effect of traditional Anjebar booali daroo medicine and Mefenamic acid on abnormal uterine bleeding in women with high vaginal bleeding and age range of 20 to 45 years.

Clinical trial with drug and control group with parallel and randomized triple blind groups

In this study, patients who referred to Izadi hospital due to vaginal bleeding were included. Patients enter the study after entering the study, clinical examination and interview with a specialist physician. In this study, patients will randomly receive a Anjebar booali daroo syrup with placebo capsule, and the other group will receive a mefenamic acid capsule each month with a placebo syrup. Treatment duration is 3 menstrual cycles and severity of bleeding, quality of life and pain will be measured at the end of each cycle.A randomized, controlled, triple-blind clinical trial.

Inclusion criteria: Patient satisfaction, bleeding more than 7 days or periods less than 21 days, Married women, Ages 20 -45 years, The Pap smear is normal, Blood tests is normal, Endometrial thickness in ultrasound is normal. Exclusion criteria:Hormone Therapy Pregnancy and lactation, diabetes, kidney disease, coagulants and cancers Hypothyroidism and hyperthyroidism, Sub-mucosal or intramural fibroids larger than 5 cm, Active gastrointestinal bleeding, Hemophilia

Anjebar booali daroo syrup and placebo syrup. ake 15 ml every eight hour and Placebo capsule 250mg( pharmaceutical company Booali Daroo)Take one capsule every eight hour.Control:Placebo syrup(pharmaceutical company Booali Daroo).Take 15 ml every eight hour and Mefenamic acid capsule 250mg( pharmaceutical company Amin) Take one capsule every eight hour In three consecutive menstrual cycles.

severity of bleeding , quality of life and pain

The way to select groups is that they will be assigned to groups based on block randomization. Blocks of size 4 are considered. So we will have six blocks containing AABB, ABAB, BBAA, BABA, ABBA, BAAB. Each block will also be randomly selected using a dice throw. For example, if thrown dice is 3, the BBAA block is considered, and therefore the first two patients are assigned to treatment B and the next two patients to treatment A. The dice will be thrown 20 times to complete the assignment of patients to the treatment groups.

Anjebar syrup and placebo syrup are introduced into uniform, colorless pets and the color of the two syrups are matched using the authorized pharmaceutical colors. Mefenamic acid capsules and placebo capsules are also packaged in identical shells and packaged in flacons containing 70 capsules. Each drug is then recorded on the same basis as drug name, batch number, proprietary drug use, drug use, and period of use. The two drugs are packaged in the same form.The differentiation of each drug is a number extracted from the randomization list and provided to the executor as codes A and B.