The Effects of spinal stabilization exercise and Vitamin D intake on the levels of tumor necrosis factor-α and interleukin-10 in women with Chronic Low Back Pain

Compare of the effects of spinal stabilization exercise and vitamin D intake on tumor necrosis factor-α and interleukin-10 levels in women with chronic Low back pain

This quasi-experimental study was conducted using a pretest-posttest design with a control group in a single blind manner. The subjects were randomly divided into four groups of control, exercise, vitamin D and combination. The training and combination groups perform 8 weeks of spinal stabilization exercises. Vitamin D and combination groups will receive 50,000 units of Vitamin D per week for 8 weeks.

The statistical population includes adult female patients with chronic low back pain referred to Ghaemshahr physiotherapy centers. Back bone stabilization exercises consist of 3 sets of 8 stretching and isometric exercises with one minute rest between exercises, three sessions per week, performed for 8 weeks at the Ghaemshahr Cultural Physiotherapy Clinic. Subjects in the vitamin D and combination groups, vitamin D and exercise and control groups, will receive placebo in a single blind manner.

Inclusion criteria: being non-athlete, having low back pain for more than three months, having a moderate pre-test VAS score Exclusion criteria: Smoking, using specific medications, becoming pregnant

Intervention group 1: This group will do 3 sessions of spinal stabilization exercises for 8 weeks and will take placebo weekly. Intervention group 2: receive 50,000 IU of vitamin D per week. Intervention group 3: This group will receive 50,000 IU vitamin D with spinal stabilization exercises. Control group: Only placebo will be taken weekly.

25- hydroxy vitamin D; Tumor necrosis factor-α; interleukin-10; C Reactive protein; Pain; Functional Disability;Sleep quality; quality of life; lipid profile; liver enzymes, renal enzymes

The subjects will be divided into four groups of control, exercise, vitamin D and combination (exercise + vitamin D) using simple randomization table. First a number is assigned to each person. Then, using the random number table of each selected number, it is assigned to one of the groups at random and will continue until the number of individuals in each group is completed. Therefore, the researcher will have no option to change or predict the status of individuals. Random concealment will be done by a third person who does not participate in other stages of intervention.

Participants, evaluators, and analysts will be blind. The researcher will administer vitamin D capsules (50,000 units) to vitamin D and combination (vitamin D + exercise) individuals as well as placebo to control and exercise groups

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