Evaluating the effect of selected natural product (Bore armani and Raphanus niger Mill. combination/mixture) compared to placebo in the treatment of kidney stones, a double-blind study

Evaluating the effect of selected natural product (Bore armani and Raphanus niger Mill. combination/mixture) compared to placebo in the treatment of kidney stones

A randomized, double-blind, placebo-controlled clinical trial study was performed on 70 patients with kidney stones 10 mm smaller than those diagnosed by ultrasound.

Patients with kidney and ureteral stones with a size of less than 10 mm who refer to Shariat Panahi Clinic, after the doctor's opinion, enter this study of two blind sides (the patient and the researcher are blind). Patients drink the medicine half an hour before breakfast and half an hour before lunch and half an hour before dinner in the evening with a glass of warm water sweetened with a tablespoon of honey. In order to evaluate the effectiveness and safety of the drug, it will be evaluated.

Patients with kidney stones 10 mm in size and smaller than those diagnosed by ultrasound are performed. Inclusion criteria: 1. Age: 20-60 years 2. Kidney or ureteral stones less than 10 mm in size, according to ultrasound reports 3. Absence of emergency conditions in the patient 4. Non-pregnancy and lactation in women 5-Creatinine blood less than 1.4 mg / dl 6. No kidney tumors 7. No insulin-dependent diabetes 8. Not taking any herbal medicine to excrete kidney stones Exclusion criteria: 1- Uncontrollable pain 2. Emergency cases of kidney stone or need for surgical intervention

We will compare the effect of natural medicine and placebo during treatment on the patients with a size less than 10 kidney stone

Comparison of renal stone size by renal ultrasound and 24-hour urinary calcium, magnesium, citrate and oxalate levels, also liver enzymes (ALT,AST), creatinine, blood urea nitrogen (BUN) in the two groups before and after drug administration.

Blocked randomization. Block randomization is used with 4 blocks, which will be used to generate random sequences using Random Allocation software. Due to randomly generated sequences, patients enter the control and intervention groups. As these patients will be referred by the treating physician to the planter, a list of the names of the nominees will be provided with a row number, and a coin will be used to decide whether or not to assign the numbers to the intervention group.

In this plan, the drug and placebo are prepared by the pharmacist. After preparing the drug, the pharmacist will insert a specific code of the medicine on the bottle. These codes are only available to the pharmacist, and no one knows what kind of medicine (medicine or placebo) until the end of the study. The shape and size of all drugs are the same and indistinguishable. Therefore, the project implementer uses the drugs randomly for each patient. At the end of the study, after collecting the data, with the help of a pharmacist, the codes related to the drug and the drug facade are distinguished from each other, but information about the drug and placebo is hidden for the analyzer. Only at the end of the study, The codes are decrypted and the necessary information is provided to the executor.

Information on changes in urinary, blood, and sonographic parameters of patients

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In charge of Dr. Reza Ilkhani's plan. Email: ilkhanir@sbmu.ac.ir

Email information to Dr. Ilkhani will be provided if he so desires and with the research assistant of Shahid Beheshti Traditional School of Medicine approve