Investigation of the effect of Zufa syrup on clinical symptoms in the with suspected Corona(COVID-19)

Investigation of the effect of Zufa syrup on clinical symptoms in the patients with Corona (COVID-19)

A randomized, controlled, Triple-blind clinical trial with 130 samples

Patients who refer to the clinic that meet the study entry criteria will be selected by the researcher, then explain the study details, Then, a questionnaire including demographic data and disease information is compiled and Patients were randomly assigned to one of two treatment groups.

Inclusion criteria:Age between 20-70/Lung tissue involvement due to CT scan/Need for medication prescribes Coronavirus treatment/Patients who are treated at home.Exclusion criteria:Heart, lung, liver and kidney disease/Blood pressure above 160 mm Hg/Fever above 39. C/Diabetic patients/Pregnancy and lactation

Intervention group: under treatment with Zufa syrup 6 times a day (every 4 hours) and each time 7.5 cc for 10 days made by Booali Daroo Pharmaceutical Company.Control group: under treatment with placebo syrup 6 times a day (every 4 hours) and 7.5 cc each time for 10 days made by Booali Daroo Pharmaceutical Company.

Reduce symptoms such as cough, sore throat, body Pain, headaches, Ague ,Shortness of breath

The way to select groups is that they will be assigned to groups based on block randomization. Blocks of size 4 are considered. So we will have six blocks containing AABB, ABAB, BBAA, BABA, ABBA, BAAB. Each block will also be randomly selected using a dice throw. For example, if thrown dice is 3, the BBAA block is considered, and therefore the first two patients are assigned to treatment B and the next two patients to treatment A. The dice will be thrown 33 times to complete the assignment of patients to the treatment groups. Also, the allocation of treatment to groups A and B will be based on accident (coin toss).

Zufa syrup and the Placebo syrup are inserted in the same-colored Bottles and the color of these two syrups is homogenized using the permitted pharmaceutical colors. Then, on each of the drugs, the same contents are recorded, including the name of the drug, the Batch number, the specific use of the drug, how to use the drug and the course of use, and the difference between each drug, a number extracted from the randomization group. It is engraved on the drug label. After executing and completing the sampling and completing the questionnaire by the company's formulation department, the codes of the drug are provided to the executors in the form of codes A and B to analyze the data and finally, after analyzing and preparing the final report, With this method, you can do three-way blinding.