Effect of Laris-Teucrium Polium L.and Laris-Hyssop combined herbal medicine on the prevention of covid-19 disease in high risk people exposed for corona virus: A randomized controlled field trial.

Determining the effect of combined herbal medicines on Polium and Hisspus on the prevention of coronavirus in healthy people exposed to coronavirus patients

Clinical trial with control group, with parallel groups, three-way blind, randomized, phase 3 on 300 individuals. RAS software was used for randomization.

This study is a three-way blind clinical trial in which the target population is high-risk families exposed to the coronavirus in Tabriz. Two herbal medicines, polioum, hisspus and placebo, will be used in three intervention groups at a daily dose of 10 cc for 20 days. Medicines and placebo are prepared in similar bottles of 500 ml. Blinding is done for the researcher, the patient, and the analyzer.Tracking of the status of people taking the drug will be done every five days by phone call and filling out the information form about the occurrence or non-occurrence of coronary artery disease symptoms and the possible occurrence of side effects caused by drug use. The research results will be statistically analyzed using SPSS version 21 / software.

Inclusion criteria: 1) High-risk people exposed to the coronavirus 2) Age 7 years and older 3) Having a conscious consent form signed to participate in the study 4) Lack of simultaneous participation in other clinical trials Exclusion criteria: 1) People with suspicious, probable or definite symptoms of the disease and need hospitalization or receiving Corona medication on an outpatient basis and their families 2) Pregnant women 3) Breastfeeding women 4) Having liver or kidney failure

Intervention groups include three groups receiving Polium, Hisspus, and placebo.

The incidence of dry cough, fever, sore throat, shortness of breath, shivering, proprietary testing positive for coronavirus

Six and nine blocking with allocation ratio of 1: 1: 1 into three groups consisting of two intervention groups and one control group Darnma using computer software RAS (Random Allocation Software)

Laris-Teucrium Polium L.and Laris-Hyssop, and placebo drugs will be prepared in exactly similar 500 ml bottles and will be numbered based on random allocation sequences. Drug recipients, researchers, data analysts, and data monitoring and safety boards will be blind to the received intervention.