The effect of zinc sulfate and folic acid on endocrine indices, CRP and lipid profile in women with polycystic ovary syndrome in 2017-18.

The effect of zinc sulfate and folic acid on endocrine indices, CRP and lipid profile in women with polycystic ovary syndrome

Clinical trial with control group, double-blind, randomized, on 44 patients. The table of random numbers was used for randomization.

44 women who aged 18-40 years old with polycystic ovarian syndrome were included in the study according to Rotterdam criteria. Prior to intervention, laboratory factors such as fasting blood sugar (FBS), Dehydroepiandrosterone sulfate (DHEAS), Testosterone, Cholesterol, Triglycerides, High density lipoprotein (HDL) and Low-density lipoprotein (LDL) was measured in subjects. Patients were randomly divided into 4 groups using the random number table and the first group received 220 mg zinc sulfate, the second group were administered 5 mg folic acid, the third group received220 mg zinc sulfate plus 5 mg folic acid and the fourth group received placebo. All groups received medication or placebo daily for 8 weeks and were re-evaluated for laboratory tests.

1.Oligoovulation or / and anovulation; 2.Clinical symptoms (Ferriman-Gallwey score≥6 or Acne or Seborrhoeic) or biochemical hyperandrogenism; 3. Evidence of polycystic ovaries on ultrasound

The final number of participants after considering the entry and exit criteria randomly and using a table of random numbers is divided into 4 groups and the first group 220 mg of zinc sulfate (containing 50 mg of zinc), the second group 5 mg of acid Folic acid, the third group will receive 220 mg of zinc sulfate (containing 50 mg of zinc) + 5 mg of folic acid and the fourth group, which is the control group, will receive a placebo daily for 8 weeks.

FBS; DHEAS; Testosterone; CRP; Cholesterol; LDL; HDL; TG; drug (folic acid + zinc sulfate)

Random number table; to use a table of random numbers, the exact number of people in the community was first determined and coded in order. Then, to select sample people from the table, we randomly start from a point in the table in the direction of the row or column. The selected number is in fact the individual code of the community that is selected as the sample. We will continue to do this until a small number can be selected based on the number of sample people. After completing the sample size, the sampling work is completed.

All drugs and placebo were prepared in exactly the same drug form and packaged and coded in dark envelopes. As a result, the patient and the researcher were unaware of the group of people