Comparison of the effect of aromatherapy and edible rose essential oil on saliva cortisol level and quality of life of chronic renal failure patients undergoing hemodialysis

Determining and comparison of the effect of aromatherapy and edible rose essential oil on saliva cortisol level and quality of life of chronic renal failure patients undergoing hemodialysis.

Clinical trial without control group, with parallel groups, non-blind, randomized groups, 72 patients.

The studied population is hemodialysis patients referred to Shahid Beheshti and Shahid Jalil hospitals in Yasouj. After the approval of the research proposal by the Research Ethics Committee of Yasouj University of Medical Sciences, at the beginning of the study, questionnaires of demographic characteristics and short form of kidney disease quality of life will be completed and a saliva sample will be taken early in the morning. One month later, the patient's saliva will be collected again using ELISA kits to measure the salivary cortisol level and the short-form kidney disease quality of life questionnaire will be completed.

Inclusion criteria: 1. At least three months have passed since hemodialysis. 2. Doing dialysis at least 2 to 3 times a week Exclusion criteria: 1. Allergy to Rosa damascene and patient reaction to it 2. Taking anti-anxiety and anti-depressant drugs

The two intervention groups will be aromatherapy and oral intake. In aroma therapy group, when the patient is connected to the dialysis machine, a piece of cloth soaked in 3 drops of rose essence with a concentration of 2% is attached to the patient's collar and the patient will be asked to breathe normally. This work will be done 3 times a day and each time for 5 minutes for 4 weeks. In oral intake group when the patient is connected to the dialysis machine, 15 drops of rose extract will be poured into some water and every 8 hours given to him/her (3 doses in day).

Salivary cortisol levels and Quality of life

Eligible participants will be selected by purposive sampling from the available population and will be allocated through random block allocation to intervention group No.1 (aromatherapy) and intervention group No.2 (oral intake). In this way, by multiplying the number of studied groups (two groups) by 2, the number of samples of each block was calculated as 4. Then, through factorial calculation, the number of blocks resulting from all arrangement modes of people was calculated as 24 blocks (4! = 4 x3 x2 x1 = 24). Possible arrangement blocks of people will be A (gray dummy) for the intervention group No.1 (aromatherapy) and B (white dummy) for intervention group No.2 (oral intake). Since the number of people in each block is 4 people and the estimated sample size is 72 people, therefore by matching 18 random numbers generated by the Sample Randomizer software, The arrangement of people in the research sample and the allocation of each number from 1 to 72 to each one of the intervention group No. 1 (aromatherapy) and intervention group No. 2 (oral consumption) will be determined. Then the block random allocation list will be compiled. In the following, patients suffering from chronic renal failure under hemodialysis will be referred and qualified research samples will be selected by fully explaining the objectives of the study. Based on the priority of the referral, a code is assigned to each of them, and by matching that number with the random block allocation list, the patients participating in the research will be assigned to one of the groups of intervention number 1 (aromatherapy) and intervention number 2 (oral intake) ) will be allocated. This process will continue until the estimated sample size is completed.