Inclusion criteria:
Aged 18 to 50 years
Healthy general condition according to medical history and initial medical examinations
Willing and able to cooperate throughout the study period according to the study protocol
Being able to fully understand the study processes and understand the explanations of the facilitators correctly
Being able to understand the contents of the informed consent form and sign it before entering the study
Allowing researchers access to medical records, test results if hospitalized due to suspicion, or approval of COVID-19
A negative pregnancy test at screening or vaccination (women only)
Using effective methods of contraception during the study (male and female)
Volunteers who agree not to donate blood, blood products, or bone marrow from the start of the vaccine until three months after receiving the last dose
Exclusion criteria:
Confirmed, suspected, or asymptomatic COVID-19 detected by PCR at baseline.
COVID-19 positive antibody
History of SARS-CoV-2 infection
History of contact with a person with SARS-CoV-2 infection (positive PCR test) during the last 14 days
People in the home quarantine period due to Covid (suspicion of exposure or suspicious symptoms)
Fever (axillary temperature greater than 37 ° C) Dry cough, extreme tiredness, nasal congestion, runny nose, sore throat, muscle aches, diarrhea, dyspnea, and shortness of breath during the 14 days prior to vaccination
Abnormality in biochemistry, blood and urine laboratory tests
History of severe allergy or allergic reactions to Inactivated vaccine components
Personal or family history of seizure, epilepsy, encephalopathy or mental disorders
Congenital malformations
History of neurologic disorders or seizure or Guillain-Barre syndrome (excluding childhood febrile seizure)
Growth disorders
Any Genetic disorder
History or signs of malnutrition
Hepatorenal diseases
Uncontrolled hypertension
Diabetes complications
BMI > 40
Any malignancy
Acute diseases or an exacerbation of a chronic disease in the last 7 days
Known case of immunodeficiency, HIV, lymphoma, leukemia, or other autoimmune diseases
Thyroid disease or history of thyroidectomy
Splenectomy or history of any organ removal
History of coagulopathy
Receiving Anti-TB treatment
Positive HBSAg
Positive HIV test
Positive HCV antibody
Receiving immunomodulators or immunosuppressors at least 14 days in the past 3 months
Receiving live vaccine in one month or other vaccines in 14 days before inoculation
History of drug or alcohol abuse
Receiving immunoglobulins or blood products in 3 months before inoculation
Receiving any other investigational drug in 6 months before inoculation
Planning to receive any vaccination in on month after inoculation
History of severe mental disorders affecting the participation in the study
Pregnant or lactating women or those who intend to become pregnant during the study period
Having a high-risk job of being exposed to the SARS-CoV-2 virus or having a high risk of exposure according to the investigator evaluation
Any other condition that makes a person inappropriate for participation based on the investigator opinion