The effects of curcumin supplementation along with pilates training on anthropometric indices, liver enzymes and lipid profile in overweight and obese women

Determining of the effects of curcumin supplementation along with pilates training on anthropometric indices, liver enzymes and lipid profile in overweight and obese women

Clinical trial with control group, with factorial groups, single-blind, randomized, phase 3 on 60 people. For randomization, block design is used.

Referral to a private clinic in Ramsar in 2021, selection of 60 people based on inclusion criteria, randomization into 4 groups, intervention and pilates training for 8 weeks, completion of the individual consent, physical activity and 24-hour recall questionnaires, receiving 5 Cc of blood before and after the intervention. Blinding of statistical analyzer, coding by a third party who does not know the details.

Inclusion criteria: Willingness to participate in the study Women between 20 to 50 years old Body mass index (BMI) between 25 to 35 (kg / m2) Exclusion criteria: Reluctance of patients to participate in the study Use of other dietary supplements, probiotics and anti-inflammatory drugs Use of any antioxidant supplements in the last 3 months Use of immunosuppressive drugs Following of special diets Change of diet or decide to lose weight Pregnancy, lactation Smokers Menopause Metabolic and chronic diseases Having surgical operation to weight loss

1) Supplement: one capsule 500 mg/d (450 mg of turmeric rhizome and 50 mg of turmeric extract), 2) Placebo: (one capsule 500 mg/d containing starch), 3) Pilates training (three times/week, 1 hour each time) and supplement one capsule 500 mg/d (450 mg of turmeric rhizome and 50 mg of turmeric extract), 4) Pilates training (three times/week, 1 hour each time) and placebo (one capsule 500 mg/d containing starch)

Liver enzymes, lipid profile and anthropometric indices

Assignment of people in each of the study groups (supplement, placebo, pilates training and supplement, pilates training and placebo) will be done by "Random allocation software" using classified randomized blocking method (block size: 4). In addition, in order to reduce selection bias error, allocation concealment will be used. This will be done by assigning unit codes (two codes A and B) to each person's capsules. In this way, 60 people will be randomly allocated to supplement (n = 15), placebo (n = 15), pilates training and supplement (15), pilates training and placebo (n = 15) groups. In fact, each person will receive a can containing code A or B, and eventually 30 people will receive cans containing code A and 30 people will receive cans containing code B. Also, 30 people in two groups will receive pilates training in addition to supplement or placebo.

In the present study, the statistical analyst will be blinded to the study groups. Before starting the study, the cans containing the respective capsules will be coded by a person other than the researcher (this person will not aware of the details of the research) to A and B, so that the type of received capsules in each group will be blinded for researcher. Also, placebo and supplement capsules will be similar in terms of color, shape, size and taste. In addition, cans containing the supplement and placebo will be quite similar.

The person's information will be confidential and the results will be as collective statistics

This clinical trial will be an research article and its protocol, results report and statistical analysis will be published to be used by therapists and researchers.

after the publication of results

All researchers who have access to clinical trials databases

Sometimes for re-analysis or for use in meta-analysis studies

Project manager

Mail to porasgarizeynab@yahoo.com