Comparison of the effect of probiotic drops pedilact and reuteflor in reducing prematurity complications in premature neonates

Evaluation and comparison of two probiotic drugs, Pedilact, Reuteflor and placebo, on the days of reaching full feeding volume , hospitalization days , days of need for oxygen therapy , daily weight gain , the incidence of necrotizing enterocolitis and neonatal jaundice in preterm neoates

Clinical trial with control group, with parallel groups, triple blind, randomized, phase 3 on 90 patients

Neonatal intensive care unit of Valiasr Hospital in Birjand, the neonates are randomly divided into three groups of numbers and each group is prescribed 5 drops of Pedilact or Reuteflor or distilled water daily for 7 days.Lack of information of the patient and medical staff involved and responsible for data collection and data analyzer of the type of drug or placebo

Inclusion criteria: Premature neonates (gestational age less than 37 weeks) with age from birth to 7 days of age at the time of feeding start with a weight of 1000 to 2000 grams and non-inclusion conditions: severe asphyxia, cerebral hemorrhage, congenital anomaly major, Premature neonatal sepsis

In each random group, preterm neonates are given 5 drops of the drug or placebo specific to that group for 7 days from the start of oral feeding.

Duration of hospitalization, time to Full enteral feeding, duration of oxygen therapy

For each neonate eligible for the study, a lottery will done by using three different color cards in three sealed envelopes to randomly place the neonate in one of the three intervention groups. It will done by one of the parents and only the researcher knows the type of intervention based on the color of the card.Information of intervention and control groups inside the numbered envelope will be opaque and sealed.

Lack of information of the patient and medical staff involved and responsible for data collection and data analyzer of the type of drug or placebo