The effect of a 1% azithromycin eye drops treatment on signs and symptoms of blepharitis

Determining the effect of azithromycin 1% treatment on the signs and symptoms of blepharitis

Clinical trial with control group, with parallel groups, double-blind, randomized, phase 3 on 90 patients. It will be done by blocking method for randomization.

This study is performed in Razi Hospital of Birjand, South Khorasan Province. 90 patients are randomly divided into two groups: 1% azithromycin or erythromycin. Then, the signs and symptoms of blepharitis in patients before and 4 weeks after treatment will be evaluated by the study leader without knowing the type of medication received by the patient.

Patients with blepharitis will be referred to the ophthalmology clinic of Razi Hospital in Birjand in 1400. Admission requirements :. Patients with anterior blepharitis between the ages of 18 and 80 and patients with eye injuries and infections, non-dry eye inflammation, surgery, and eye trauma will be excluded in the last 6 months.

Patients with blepharitis referred to an ophthalmology clinic will be randomly divided into two groups receiving 1% azithromycin (topical twice daily for 4 days) and erythromycin (topical twice daily for 4 days).

Clinical signs and symptoms of blepharitis include eye irritation, itching and burning of the eyelids, eye discomfort after working with a computer, a feeling of heaviness in the eyelids, discharge on the eyelashes, a feeling of dry eyes, sticking of the eyelids when waking up and redness of the eyes.

Participants in the study will be randomly divided into two intervention groups receiving azithromycin 1% (group A) and the control group receiving erythromycin (group B) by simple blocking method. Patients with the above conditions in two groups are randomly entered into one of the two intervention or control groups by blocking method (quadruple blocks). Thus, various quadrilateral blocks were created (AABB, BBAA, ABAB, BABA, ABBA and BABA). One of these blocks will be randomly selected and patients will be divided into one of two groups A or B. Then randomization was performed for other patients.

Outcome Assessor: The ward nurse, without knowing the type of medication received, questions the patients and records them in the relevant checklist. Participants in the study without knowing the medication received for the treatment of blepharitis, which is the gold standard treatment or the new treatment for blepharitis.