Evaluation the effect of mouth wash contains punica granatum extract in comparison with chlorhexidine mouth wash on improvement of periodontal index in chronic mild to moderate periodontitis

Evaluation the effect of mouth wash contains punica granatum extract in comparison with chlorhexidine mouth wash on improvement of periodontal index in mild to moderate chronic periodontitis.

non randomized double blind clinical trial with control group, parallel groups, third phase on 30 patients.

It will be performed at the periodontolgy department of Alborz Dental University.executor, clinical caregiver, data analyzer, outcome assessor, the person under study and data analyzer are blinded. people with all the inclusion criteria are selected and then all the required information is provided to them and if they are satisfied date of first session will be fixed.

"inclusion criteria":not smoker؛ not alcohol consumer؛ no antibiotic intake؛ not pregnant؛ no history of allergic reaction؛ no systematic diseas؛ not in breast feeding period؛ has mild to moderate chronic periodontitis. they should have mild to moderate periodontitis.

"Intervention group:" Ultrasonic scaling is performed as the first line of treatment for patients with mild to moderate periodontitis. The patient will use mouthwash for two weeks that containing 2% punica granatum extract which produced in the Faculty of Pharmacy of Alborz University of Medical Sciences twice a day and 1 minute each time. 1 month and 3 months after scaling, he refers to check and re-measure gingival indices. "Control group:" completely identical to the intervention group, only mouthwash is replaced with 0.2% chlorhexidine from NAJO company.

gingival index, pocket depth, bleeding on probing, clinical attachement loss, bacterial culture

In this study, we will use the block randomization method. This method is usually used to balance the number of samples assigned to each of the study groups. The size of all blocks is equal and in this two-group experiment, we will have 4 blocks of 8 (including 4 people participating in the intervention group and 4 people participating in the control group), Due to the possibility of people not attending the follow-up sessions, 2 people are considered more than the sample size. The site https://www.sealedenvelope.com/simple has been used for random assignment of individuals to groups. In this method we use sealed envelopes with a random sequence. Each of the random sequences created is recorded on a card and the cards are placed inside the envelopes in order. In order to maintain a random sequence, the envelopes are numbered in the same way on the outer surface. Finally, the lids of the envelopes are glued and placed inside a box, respectively. At the beginning of the registration of participants, according to the order of entry of eligible participants into the study, one of the envelopes open in order and the assigned group of the participant is revealed.

The codes for each group will be kept in a closed envelope. After the person is eligible to enter the study, based on the obtained sequence, one of the two interventions will be performed for him. The solutions are in the same jars and are similar in color and size, and no one untill the end of the study, when the research report is being prepared, neither the researcher, nor the assistant, nor the participant has any knowledge that labels A or B belong to the intervention or control group.