Evaluation of vaginal prep with chlorhexidine in comparison with normal saline before cesarean section on endometritis and post operative wound infection in the pregnant women undergoing cesarean section

Determining the effect of vaginal lavage with chlorhexidine before cesarean section on endometritis and wound infection after cesarean section

This study is a randomized controlled clinical trial (RCT). The method of random allocation will be block randomization. The minimum sample size in each group was calculated to be 140, and with 15% attrition rate was calculated 160 in each group. Patients during the first 10 days after cesarean section will be examined for symptoms of endometritis (fever 38.8 ° C or higher after 24 hours after surgery) and infection of the incision site (redness or opening of the wound edges with the appearance of purulent discharge).

This study was performed in the surgical ward of Kowsar Hospital in Qazvin city in Qazvin province. Blinding: One-way blindness Description of how to blind: Abdominal and vaginal washing will be done in two groups by the researcher. The researcher will be unaware of which group the samples are in.

Inclusion criterion: All mothers who had a cesarean section indication. Non-inclusion criteria: diabetes; Existence of severe chorioamnionitis; Excretion of meconium; Twin pregnancies and more; Prolonged rupture of the bladder (more than 18 hours).

Intervention group: In addition to rinsing the abdomen with betadine and injecting antibiotics, rinsing with sterile gas containing 0.05% chlorhexidine around and inside the vaginal opening for 45 seconds and rotating 360 degrees will be performed and receive vaginal preparation. Control group: Before starting cesarean section, abdominal rinsing with Betadine and antibiotic injection will be performed. Patients will also receive vaginal lavage with normal saline.

Occurrence of endometritis; Abdominal incision site infection.

In this study, block randomization method is used. To perform this method, the size of each block is specified at first (for example, a quadruple block). Then we write a list of blocks and assign numbers to them. (AABB (1) - ABAB (2) -ABBA (3) -BBAA (4) - BABA (5) - BAAB (6)) Then we select random numbers between one and 6 (For example, 1 4 5, etc.) and finally specify the treatment allocation list based on previous random numbers (… AABB-BBAA-BABA-).} The same procedure continues until the sample size is completed. In this way, from among the mothers of 320 people who have the inclusion criteria, they will be selected by convenience and will be divided into two groups of test and control by random block method (160 people in each group).

Due to the fact that abdominal and vaginal lavage will be performed in two groups by the researcher, endometritis and wound infection will be performed according to the mentioned criteria and the researcher will be unaware of that which sample belongs to each group.

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