Level of Metalloproteinase Matrix 8 in Gingival Crevicular Fluid of Mandibular anterior teeth with two types of fixed and removable orthodontic retainers

Determination of mean metalloproteinase matrix 8 (in pg) in mandibular anterior teeth in ESSIX and bonded retainers

Clinical trial, two parallel groups, double-blind, randomized to 30 patients, randomization by Random allocation software.

The study is performed at Shahid Sadoughi Dental School in Yazd. ESSIX retainer is bandaged for each patient in a session and in the upper jaw, and according to the group in which they are located, in the lower jaw, Retainer wire Hilgers Bond A Braid or ESSIX retainer (by Vacuum thermoforming machine is placed. The gingival fluid of these patients will be sampled on the day of debonding, 30 days later and 90 days later. In this study, the statistical consultant and the head of the laboratory become blind

Inclusion: 1-Patients have been treated with the 022 System and their treatment has been completed with satisfactory correction of malocclusion and appropriate dental alingment.2-The Patient's condition is favorable in terms of general health.3-Absence of Craniofacial Syndromes and Facial Clefts 4-Absence of severe and uncontrolled Caries 5-The Patient should have good oral hygiene and be Periodontally normal. 6-The Patient should have all the anterior Mandibular teeth and the teeth should be of normal shape and size Non inclusion:1-Lack of Patient cooperation to refer 2-Observe poor Periodontal status during the study3-Break and not using the retainer 4-Specific conditions of COVID 19 infection that prevent the Patient from visiting.

The first intervention group (15 patients) who have ESSIX at the end of treatment and the second intervention group (15 patients) who have a banded retainer at the end of treatment.

Metalloproteinase matrix level 8 after orthodontic debonding immediately after debonding, 30 days and 90 days after debonding

First, using Random allocation software version 1.0 under Windows ,we generate a random sequence using a simple random allocation method. In this table, it is specified from 1 to 22 and each number is assigned to an intervention group (A or B). The first eligible patient is assigned number 1, the second patient is assigned number 2 and so on up to 22 patients. In order to blind the random allocation of clients by a third person who is unaware of the interventions, they are placed in intervention groups (A or B) by this table.

In this study, the Patients and the researcher (who is responsible for sampling of Patients) are aware of the type of retainer in the Mandible. But the person in charge of data collection, the statistician consult who is in charge of data analysis, and the person in charge of the laboratory who will eventually analyze the samples are blinded because the information and samples of patients in all the mentioned steps will be identified only by random numbers.

After unidentifying individuals, it is possible to share all values ​​of the metalloproteinase matrix and the irrigularity index and overjet and overbite of patients in both treatment groups.

Start the access period 6 months after publishing the results

Researchers working in academic and scientific institutions and valid scientific research journals

In order to use the documents of this study for other studies and researches to apply the results

Responsible person in this field: Shiva Abdollahi , email address:sh.abdollahi.dds@gmail.com

The applicant can send his request to the above-mentioned email address with his introduction and the reason for the request and receive the information as soon as possible (finally within 7-10 days).