efficacy of platelet rich plasma versus5% topical minoxidil for the treatment of androgenetic alopecia

To determine the efficacy of Platelet Rich Plasma (PRP) versus 5% topical minoxidil for the treatment of androgenetic alopecia

randomized control trial(RCT) parallel group,single blinded study 35 patients will be assign in each group,radomization will be done by lottery method,a single center study

PNS Shifa karachi after approval from ethical committee,blinding is done for photographic examination,as mentioned earlier

inclusion criteria Age 18 to 60 years.Patient Hamilton-Norwood grade ≥2 and ≤ 5 or Ludwig scale grade 1-2.Platelets count more than150, 000 /µl.Duration of androgebetic alopecia > 6 months.Patient has not taken any kind of medical treatment for hair loss or has not used treatment for more than 6 months duration. exclusion criteria Patients with alopecia other than AGA, such as telogen effluvium, alopecia areata, acquired cicatricial alopecia, or anagen effluvium.The patient on warfarin or heparin.The infective disease of the scalp.Patient who has taken any treatment for androgenetic alopecia History of thyroid disorder.Patients with hypersensitivity to minoxidil in past.Any infective skin disease.Pregnancy /lactation.Patient taking aspirin.Unrealistic expectation.

30 ml of venous blood will be drawn into a tube containing citrate phosphate dextrose,it will be subjected to centrifugation by two spins to produce PRP .Calcium gluconate to PRP ratio used will be 1:9 this will be injected intradermally,each session 1 month apart. Participants of group B will be advised to apply topical 5% minoxidil 1 ml over dry scalp 12 hourly.

hair pull test ,investigator 7 point score ,patient satisfaction score ,patient standardized hair growth questionnaire,photographic evaluation

randomized by lottery method (each patient presenting to dermatology out patient department for androgenetic alopecia will be assigned a number and will be selected randomly so each patient has same probability to be included in the study)

response to treatment will be assessed as follows Patient hair should be dry and clean. He will be advised to maintain the same hair style and hair colour on each visit. Appropriate lightening will be used; multiple images will be shot at vertex and mid pattern. For vertex view patient will be asked to look at the ceiling. For mid pattern patient will be instructed to place hand flat on table with fingers of both hands interlocked, and now place his/her face on hand . Results will be interpreted by investigator 7 point score [14]. - 3 = greatly decreased -2 = moderately decreased -1 = slightly decreased 0 = no change 1 = slightly increased 2 = moderately increased 3 = greatly increase photograph will be taken at 0 ,3 , and 6 months one dermatologist will be blinded to the treatment group of the patient