The effect of combined capsule black pepper ،sativa linn )black cumin) and Curcuma Longa on inflammation factors and lipid profiles and acute phase proteins in patients with covid-19 hospitalized

Evaluation the effect of black pepper extract and black seed and turmeric on inflammatory factors and acute phase lipid and protein profiles in patients with Covid - 19 hospitalized

A clinical trial with a control group with parallel, double-blind, randomized, phase 3 groups on 60 patients will be randomized using randomized blocking method

all patients with Covid-19 in the age range of 20 to 70 years who are admitted to the covid-19 ward of Khatam al- Anbia Hospital in Shoushtar will be eligible to enter the study. The number of participants in each group is 30. Full explanations of the study are given and if they agree to enter the study, they will be given written consent. General characteristics questionnaire includes: age, sex, smoking, diet supplements and medications, history of disease and duration of illness and questions about taking antioxidant supplements. A placebo containing wheat flour is prepared in a similar way and in the same shape and color .The patients in the intervention group consume 3 grams of black pepper and turmeric extract daily in hard capsules (1 capsule of 500 mg after lunch and dinner).

At first, all patients with Covid-19 in the age range of 20 to 70 years who are admitted to the covid-19 ward of Khatam al-Anbia Hospital in Shoushtar will be eligible for inclusion in the study. Exclusion criteria include supplementation Less than 80% of the total is the change in the type and amount of drug used during the intervention and the unwillingness to continue cooperation in the study.

Two intervention groups with herbal capsules and the control group with placebo

CBC,blood lipids(HDL، LDL , TG, CHOLESTROLE),BLOOD SUGER, PT, PTT, blood interleukin 6, D- DIMER, ALT, AST,ALP, BILLI TOTAL , DIRECT), hs-CRP,

To control the effect of confounding factors, individuals are matched in two groups in terms of age, sex, and body mass index. Purposeful sampling is performed among patients with 19 patients admitted to Khatam Al-Anbia Hospital in Shoushtar.In this way, in random selection of samples, blocking is used with the help of computer drive button, And the method of assigning individuals to the two groups studied is a random blocking method with quadruple blocks.The blocks are selected until they reach the desired volume (60 patients) based on a table of random numbers.

All steps to be double-blind will be performed by a third party after the coding steps, which means that researchers providing care and patients will not have information on the complementary type until the end of the study. In order to further ensure that the selection bias does not occur after random allocation, the allocation conciliation method will be used by using unique two-digit codes for each person.