Comparision the efficacy of 2 regimen of methylprednisolone in patient with acute respiratory distress syndrome due to CVOID-19

Determining the mortality rate of patients during hospitalization in both groups of pulse methylprednisolone group and 1 mg/per kiloogram of body weight every 12 hours.

The trial has two study groups in parallel, randomized, non-blind phase 3 on 74 patients and uses rand function of excel for randomization

Patients with mild to moderate acute respiratory distress syndrome who admit to corona ward of Loghman Hakim hospital will go under study with two different regimen of methylprednisolone doses.

inclusion criteria: Patients older than 18 Patient with severe acute respiratory injury with symptoms of novel coronavurus during 10 recent days Posotive polymerase chain reaction (PCR) test of novel coronavirus or chest CT scan that confirms coronavirus pneumonia Mild to moderate acute respiratory distress syndrome No more than 24 hours have passed since their admission. The patient should not be under invasive mechanical ventilation when entering the study. Satisfaction to participate in the study. Exclusion criteria: Dissatisfaction of the patient or the patient's legal companion. Pregnancy and lactation. Chronic hemodialysis Heart failure Severe vasoplegic shock Pulmonary edema due to other pathology like heart failure , cirrhosis , chronic kidney failure Severe hypoxemia If patient expires lower than 3 days after beginning of treatment.

One group recieves 1 mg per kg of methylprednisolone every 12 hours and other one recieve 1000 mg of methyl prednisolone daily for 3 days then keep on with 1 mg per kg every 12 hours.

mortality ratio

First, by randomized numbers list, a sequence of random numbers will be selected and patients will be allocated to interventions groups with simple randomization.