Administration of Zinc-Chelating Agents (intravenuosly CaNa2EDTA) in COVID-19 Patients: A pilot study

Evaluation of blood cells, blood pressure, blood oxygen, albumin, total protein,ALT, AST, ALP, LDH, LDL,HDL, Cholesterol, Triglyceride, CRP, Pro-Calcitonin, IL-6, Pro-BNP, D-dimer, in patients receiving EDTA and control group

In this study, 100 people who are divided into two groups of control and treatment will enter the study. And are categorized completely randomly.

The prescribing strategy is based on the minimum effective dose for each patient in Ghaem Asadabad Hospital. In order to tailoring of medical treatment to the individual characteristics of each patient (precision medicine) and to avoid adverse effects, an administration strategy based on the minimal effective dose (which can be different depending on the patient and disease condition) for each patient will be pursued. To this aim, it is proposed to start with 100 mg/m2 every 8 hours (3 times a day).

The study population is the total number of patients admitted to the Intensive Care Unit (ICU) of Ghaem Hospital, Asadabad, who was admitted to that ward due to respiratory distress caused by Covid-19 disease. After the researchers explain the goals of the project, the patients who sign the consent will enter the research. Exclusion criteria included diabetic patients taking insulin, patients with urinary tract problems, patients with cardiovascular problems, and people who did not sign the consent form.

Control group: Receiving common medications for Covid-19 in the ICU Treatment group: Receiving common drugs for for Covid-19 in the ICU + a dose of 50 to 100 mg of calcium EDTA three times a day intramuscularly or intravenously for 2-3 days and 5 days if needed

Improve oxygen supply

Randomization method: Simple randomization Randomization tool: Random number table Random number table is a set of numbers that are produced without a specific pattern or order and in a completely random form and has become a table. In order to use the table of random numbers, we first predetermined the table to read the numbers (for example, up, down, left or right), then we assumed that the numbers should be used for different study groups.

There is no more information.

If the results of the study are positive for the treatment of patients, the protocol will be reported.

Access period starts 3 months after the results are published

All people working in health care centers, and academic and scientific institutions

There will be no restrictions on the use of data

Correspondence with e-mail address

Send an email to the investigator to receive the data clearly stating the reason for receiving the data