To assess the efficacy of oropharyngeal colostrum therapy on short outcome among preterm neonates

To assess the efficacy of oropharyngeal colostrum therapy on short outcome among preterm neonates

This clinical trial study is designed as a double-blind, randomized placebo control group, and 126 preterm infants divided into 2 Groups are identified as groups A and B. The performer and the collector are not aware of the actual names of the group's The cards shuffling method is used for refinement.

To hide the random allocation process, the order of interventions will be written on 126 cards and each card will be placed in an envelope.

Inclusion criteria for premature infants under 32 weeks or weighing less than 1500 grams are hospitalized in the intensive care unit of Fatemieh Hospital in Hamadan. The exclusion criteria are genetic and chromosomal disorders, HIV-positive mothers, and drug-addicted mothers—any case where there is a contraindication for milk feeding for the baby.

63 infants received 0.2 ccs of their mother's colostrum through the oropharynx every 6 hours to 3 days from birth to the first 72 hours of birth. The other 63 infants were placebo and received 0.2 ccs of distilled water. And due to the apparent difference between distilled water and colostrum, the syringes are covered with white paper glue and the appearance of colostrum or distilled water is not seen.

Short-term prognosis of mortality and incidence of necrotizing enterocolitis and ventilator-associated pneumonia and the incidence of cerebral hemorrhage and the incidence of definite and clinical infections and the duration of hospitalization and the duration of complete oral nutrition in these infants and the rate of neonatal retinopathies Premature babies who need laser surgery are examined. The studied neonates will be monitored for a short period of up to one month.

In the method, the mother's colostrum was given oropharyngeal every six hours for three days, starting from birth to the first 72 hours of the baby's birth.

Our sample size is 126, which is done by the cards or envelopes shuffling method. In this method, a number of cards selected by the researcher as group A and the same number of cards for group B are considered. This card will be returned to the other cards after leaving.

The list of random allocation of patients will be available only to the epidemiologist of the project. To hide the random allocation process, the order of interventions will be written on 126 cards and each card will be placed in an envelope (with a suitable thickness that it is not possible to read the type of intervention on the cover of the envelope). When the interviewer declares a baby eligible, the methodologist will provide the group with an intervention plan. The person evaluating the intended outcomes is a third party who is unaware of the random allocation process and the type of treatment performed. For data analysis, a statistician who is separate from the study process and is unaware of all the processes performed will be used.

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