Assessment of intravenous of vitamin C therapeutic effects on laboratory findings in covid-19 patients

Determining and comparing the therapeutic effects of intravenous vitamin C injection on laboratory findings in covid-19 patients

A clinical trial with a control placebo group; parallel groups; single-blind; phase 3; performed on 90 patients; using Random Allocation Software.

The study is a one-sided blind clinical intervention .Initially, 90 patients with covid-19 who were admitted to Taleghani hospital wards were divided into two groups of 45 receiving standard treatment with intravenous vitamin C (intervention group) and receiving only standard treatment (control group).The intervention includes injection of vitamin C in amount of 1.5 gr for each patient in the intervention group by intravenous infusion ,using normal saline 500 cc in 4 hours, at the moment of entering the ward. Both study groups will receive all standard procedures and treatment, equally, but do not know which placebo to inject and which drug.

Inclusion criteria: Adults (age 18 years or older); SPO2<92%; Being treated in the ward; Positive PCR test; Involvement of Chest-CT-Scan. Exclusion criteria: Patients with a history of allergy to vitamin C; Patients with dyspnea caused by cardiogenic pulmonary edema; Pregnant and Lactating women; Patients with a previous history of end-stage pulmonary disease, end-stage malignant tumor, diabetic ketoacidosis, severe kidney disease; Active kidney stone disease

The intervention includes injection of vitamin C in amount of 1.5 gr for each patient in the intervention group by intravenous infusion ,using normal saline 500 cc in 4 hours, at the moment of entering the ward and for control group ,a placebo with the above specification is injected.

WBC ,CRP ,ESR , AST ,ALT ,ALK.P, PT ,PTT ,INR ,LDH ,Ferritin , D-dimer , duration of hospitalization ,death

Patients are divided into two groups of vitamin C treatment (intervention group) and the control group using Block Randomization Method. Initially, 6 blocks are prepared with the AAABBB combination and all possible modes of this combination are listed. A specific code is then assigned to each combination. Then, according to the sample size and the volume of the blocks, 14 blocks are selected ,using randomization method .All this process is done, using Random Allocation Software under the supervision of an epidemiologist.

All participants in this study are divided into two groups, receiving vitamin C (intervention group) and the control group, but expect for health staff, no patient knows that the placebo was injected or vitamin C. So only patients in this study are blind.