Inclusion criteria:
Iranian and resident of Mashhad
Literacy for reading and writing
Phone number to call
At least 12 months after the last normal menstruation or FSH> 40 and a maximum of one year after the last normal menstruation
Healthy Pap smear: if the Pap smear is Liquid based from 5 years ago and the traditional Pap smear is from 3 years ago
Complaints of hot flashes: on average during 2 weeks of screening, having moderate or severe hot flashes 5 or more times a day
Not receiving estrogen or progesterone for the past three months
No spotting in the past year
Do not use tobacco (cigarettes, hookah and drugs) and alcohol
No tragic events in life in the last 6 months: Death of spouse, children or close family members, severe illness of family members, major change in employment and life, dismissal or unemployment of self or spouse Severe family dispute or divorce
Do not use medications to reduce the symptoms of hot flashes for the past 1 month: Hormonal contraceptives, venlafaxine, paroxytin, fluoxetine, gabapentin, clonidine, vitamin E supplements, bromocriptine, oral naloxone, veralipride, yoga, acupuncture, citalopram, sertraline, pre-gabapentin, relaxation techniques
No chronic diseases: Cardiovascular, liver disorders, skin diseases, thyroid disorders
Lack of sensitivity to Heracleum persicum: Includes any changes and skin allergies and sensitivity to sunlight
Do not use medicinal plants containing phytoestrogens: including soybeans, flaxseed, licorice, fenugreek, fennel, hops, sage, red clover, black cohosh
Exclusion criteria:
Major changes in nutrition and physical activity patterns: Starting exercise programs
Use of medicinal plants containing phytoestrogens during the study: including soybeans, flaxseed, licorice, fenugreek, fennel, hops, sage, red clover, black cohosh
use medications to reduce the symptoms of hot flashes for the past 1 month: Hormonal contraceptives, venlafaxine, paroxytin, fluoxetine, gabapentin, clonidine, vitamin E supplements, bromocriptine, oral naloxone, veralipride, yoga, acupuncture, citalopram, sertraline, pre-gabapentin, relaxation techniques
Do not fill out the hot flush questionnaire for 3 days or more in a week
Do not take the drug for 2 days or more
Occurrence of symptoms of allergy to heracleum persicum during the study: includes any changes and skin sensitivity and sensitivity to sunlight, including any changes and skin sensitivity and sensitivity to sunlight