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Evaluation of therapeutic effect of Glycyrrhiza glabra plant in improving and accelerating the treatment of patients with Covid 19

Protocol summary

Study aim
Evaluation of therapeutic effect of licorice in the treatment of Covid 19
Design
1- The study includes 50 patients referred to Valiasr clinic with the age 18 to 60 years who are diagnosed with mild covid . 2- informed consent will be obtained from all of them . It should be noted that all these patients will also receive routine treatment of Corona. 3- The criteria for entering the study include having a mild corona virus, being in the age group of 18 to 60 years, not having a history of specific diseases, not having specific drug interactions, and exclusion criteria includes; acute corona infection, having an specific disease such as cardiovascular diseases, having autoimmune diseases, having drug interactions, pregnancy. 4- On day zero, ten milliliters of blood will be collected from patients 5- For one week, patients receiving 300 mg of licorice daily in the form of capsules . 6- After 7 days again, 10 ml of blood will be collected from patients. 7- interleukin 1,6 and CRP and blood cells check and the results before and after will be compared.
Settings and conduct
The study will be conducted at Valiasr Clinic . At the beginning , 10 ml of blood will be taken , then the patients will be given 300 mg of licorice daily for one week , then blood will be taken again, the level of interleukin 1,6, CRP, and the blood cells will be counted .finaly the results will be compared Before /after the study.
Participants/Inclusion and exclusion criteria
inclusion criteria:The age 18 to 60 years old, having no specific diseases, having no drug interactions. exclusion criteria:Having acute corona, having specific disease such as CVD, having autoimmune diseases, having drug interactions, pregnancy
Intervention groups
50 mild covid patients who will receive 300 mg licorice daily for one week
Main outcome variables
IL1,6, CRP,CBC

General information

Reason for update
Acronym
IRCT registration information
IRCT registration number: IRCT20220712055444N1
Registration date: 2022-07-26, 1401/05/04
Registration timing: prospective

Last update: 2022-07-26, 1401/05/04
Update count: 0
Registration date
2022-07-26, 1401/05/04
Registrant information
Name
alireza ahmadzadeh
Name of organization / entity
Country
Iran (Islamic Republic of)
Phone
+98 21 23871
Email address
a.ahmadzadeh@sbmu.ac.ir
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2022-08-23, 1401/06/01
Expected recruitment end date
2022-11-21, 1401/08/30
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Evaluation of therapeutic effect of Glycyrrhiza glabra plant in improving and accelerating the treatment of patients with Covid 19
Public title
Evaluation of therapeutic effect of Glycyrrhiza glabra plant in the treatment of patients with Covid 19
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
The age group is 18 to 60 years old, having no history of specific diseases, not having drug interactions
Exclusion criteria:
Having acute corona, having an specific disease such as cardiovascular diseases, having autoimmune diseases, having drug interactions, pregnancy
Age
From 18 years old to 60 years old
Gender
Both
Phase
N/A
Groups that have been masked
  • Outcome assessor
  • Data analyser
Sample size
Target sample size: 50
Randomization (investigator's opinion)
N/A
Randomization description
Blinding (investigator's opinion)
Single blinded
Blinding description
All patients have the same conditions for receiving licorice.Blinding is done only for the evaluator
Placebo
Not used
Assignment
Single
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethic committee of shahid beheshti university of medical sciences
Street address
7th Floor, Bldg No.2 SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, Iran.
City
Tehran
Province
Tehran
Postal code
19839-63113
Approval date
2022-06-28, 1401/04/07
Ethics committee reference number
IR.SBMU.RETECH.REC.1401.145

Health conditions studied

1

Description of health condition studied
patient with mild Covid19
ICD-10 code
B34.2
ICD-10 code description
Coronavirus infection, unspecified

Primary outcomes

1

Description
IL6,IL1,CRP,WBC
Timepoint
7 days
Method of measurement
Elisa kits and Blood cell counting machine

Secondary outcomes

empty

Intervention groups

1

Description
Intervention group: In addition to routine treatment, mild covid patients will receive 300 mg licorice for 7 days.This study is before/after and has no control group
Category
Treatment - Other

Recruitment centers

1

Recruitment center
Name of recruitment center
valiasr Hospital
Full name of responsible person
alireza ahmadzadeh
Street address
Ilam Province, Darreh Shahr,Shahid Jafari AVE
City
darreshahr
Province
Ilam
Postal code
1971653313
Phone
+98 21 2271 8531
Email
a.ahmadzadeh@sbmu.ac.ir

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Shahid Beheshti University of Medical Sciences
Full name of responsible person
alireza ahmadzadeh
Street address
7th Floor, Bldg No.2 SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, Iran.
City
tehran
Province
Tehran
Postal code
22721150
Phone
+98 21 2271 8531
Email
a.ahmadzadeh@sbmu.ac.ir
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Shahid Beheshti University of Medical Sciences
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
Shahid Beheshti University of Medical Sciences
Full name of responsible person
alireza ahmadzadeh
Position
associate professor
Latest degree
Ph.D.
Other areas of specialty/work
Medical Biology
Street address
t 7th Floor, Bldg No.2 SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, Iran
City
tehran
Province
Tehran
Postal code
1971653313
Phone
+98 21 2271 8531
Email
a.ahmadzadeh@sbmu.ac.ir

Person responsible for scientific inquiries

Contact
Name of organization / entity
Shahid Beheshti University of Medical Sciences
Full name of responsible person
alireza ahmadzadeh
Position
associate professor
Latest degree
Ph.D.
Other areas of specialty/work
Medical Biology
Street address
t 7th Floor, Bldg No.2 SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, Iran
City
tehran
Province
Tehran
Postal code
1971653313
Phone
227118531
Email
a.ahmadzadeh@sbmu.ac.ir

Person responsible for updating data

Contact
Name of organization / entity
Shahid Beheshti University of Medical Sciences
Full name of responsible person
alireza ahmadzadeh
Position
associate professor
Latest degree
Ph.D.
Other areas of specialty/work
Medical Biology
Street address
t 7th Floor, Bldg No.2 SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, Iran
City
tehran
Province
Tehran
Postal code
1971653313
Phone
227118531
Email
a.ahmadzadeh@sbmu.ac.ir

Sharing plan

Deidentified Individual Participant Data Set (IPD)
Undecided - It is not yet known if there will be a plan to make this available
Study Protocol
Undecided - It is not yet known if there will be a plan to make this available
Statistical Analysis Plan
No - There is not a plan to make this available
Informed Consent Form
Undecided - It is not yet known if there will be a plan to make this available
Clinical Study Report
Undecided - It is not yet known if there will be a plan to make this available
Analytic Code
Undecided - It is not yet known if there will be a plan to make this available
Data Dictionary
Undecided - It is not yet known if there will be a plan to make this available
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