Protocol summary

Summary
The aim of this study is comparing the changes of VAS score and BRS before receiving green tea and 8 hrs after operation. This clinical trial is performed on patients undergoing tibia surgery in Poorsina hospital in Rasht, Iran. After obtaining a history, physical exam and 12 lead ECG, venous blood is obtained for baseline biochemical serum measurements, as well as CBC- ALT- AST- BUN- Cr-ALKP. The inclusion criteria are the patient aged between 30-65 years old candidate for tibia fracture surgery daily consumed of black tea are not more than 2 tea bags or 4g loose tea/day. The exclusion criteria are cognitive or psychiatric disorders; history of any drug abuse, hepatic and renal diseases; pregnancy and breast feeding. All participants meeting inclusion criteria provided with informed consent. In this double blind clinical trial participants are randomly assigned to two groups of green tea and placebo by triple blocks. The anesthesia method and pain control are the same in two groups, green tea (n=30) and placebo (n=30). In green tea group, patients receive a cup of green tea 2hrs before and 6hrs after operation. In two groups pain severity and relaxation are evaluated based on VAS score and BRS by a person who is not aware of the type of drink .Then the results will be compared between two groups.

General information

Acronym
IRCT registration information
IRCT registration number: IRCT201504076186N9
Registration date: 2015-04-09, 1394/01/20
Registration timing: prospective

Last update:
Update count: 0
Registration date
2015-04-09, 1394/01/20
Registrant information
Name
Bahram Naderi Nabi
Name of organization / entity
Guilan University of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 13 3323 4600
Email address
naderi_bahram@gums.ac.ir
Recruitment status
Recruitment complete
Funding source
Guilan University of Medical Sciences
Expected recruitment start date
2015-05-22, 1394/03/01
Expected recruitment end date
2015-12-10, 1394/09/19
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
The Effectiveness of Green Tea on Post operation Relaxation and Pain in Tibia Surgery
Public title
Effect of Green Tea on Relaxation and Pain
Purpose
Prevention
Inclusion/Exclusion criteria
The inclusion criteria are the patient aged between 30-65 years old candidate for tibia fracture surgery; daily consumed of black tea are not more than 3 tea bags or 4 diluted ones.The exclusion criteria are cognitive or psychiatric disorders; history of any drug abuse; hepatic and renal diseases; pregnancy and breast feeding.
Age
From 30 years old to 65 years old
Gender
Both
Phase
2-3
Groups that have been masked
No information
Sample size
Target sample size: 60
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Double blinded
Blinding description
Placebo
Used
Assignment
Parallel
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethics committee of Guilan University of Medical Sciences
Street address
Shahid Beheshti Freeway
City
Rasht
Postal code
4193833697
Approval date
2015-02-24, 1393/12/05
Ethics committee reference number
1930596705

Health conditions studied

1

Description of health condition studied
pain and relaxation
ICD-10 code
Y55.1
ICD-10 code description
Skeletal muscle relaxants [neuromuscular blocking agents]

Primary outcomes

1

Description
Pain
Timepoint
2 hours before surgery and 6 hours after surgery
Method of measurement
VAS score

2

Description
Relaxation
Timepoint
2 hours before operation and 8 hours after operation
Method of measurement
Behavior Relaxing Scale

Secondary outcomes

empty

Intervention groups

1

Description
Intervention 1) Green Tea, a cup of tea; two hours before and 6 hours after surgery.
Category
Treatment - Drugs

2

Description
Intervention 2) A cup of warm water; two hours before and 6 hours after surgery.
Category
Placebo

Recruitment centers

1

Recruitment center
Name of recruitment center
Poursina Hospital
Full name of responsible person
Bahram Naderi Nabi
Street address
Porsina Hospital
City
Rasht

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Vice chancellor for research of Guilan University of Medical Sciences
Full name of responsible person
Abtin Heidarzadeh
Street address
Shahid Beheshti Freeway
City
Rasht
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Vice chancellor for research of Guilan University of Medical Sciences
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty

Person responsible for general inquiries

Contact
Name of organization / entity
Guilan University of Medical Sciences
Full name of responsible person
Bahram Naderi Nabi
Position
Anesthesiologist
Other areas of specialty/work
Street address
Poursina Hospital
City
Rasht
Postal code
4139638459
Phone
+98 13 3331 0434
Fax
+98 13 3334 5132
Email
arcguilan1392@gmail.com
Web page address
www.arc.gums.ac.ir

Person responsible for scientific inquiries

Contact
Name of organization / entity
Guilan University of Medical Science
Full name of responsible person
Bahram Naderi Nabi
Position
Anesthesiologist
Other areas of specialty/work
Street address
Poursina Hospital
City
Rasht
Postal code
4193955599
Phone
+98 13 3331 0434
Fax
+98 13 3334 5132
Email
arcguilan1392@gmail.com
Web page address
www.arc.gums.ac.ir

Person responsible for updating data

Contact
Name of organization / entity
Guilan University of Medical Sciences
Full name of responsible person
Hedyeh Nemati
Position
Medical laboratory Sciences Technician/ Bachelor's Degree
Other areas of specialty/work
Street address
Poursina Hospital
City
Rasht
Postal code
4193713194
Phone
+98 13 3331 0434
Fax
+98 13 3334 5132
Email
arcguilan1392@gmail.com
Web page address
www.arc.gums.ac.ir

Sharing plan

Deidentified Individual Participant Data Set (IPD)
empty
Study Protocol
empty
Statistical Analysis Plan
empty
Informed Consent Form
empty
Clinical Study Report
empty
Analytic Code
empty
Data Dictionary
empty
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