Biological and Pharmacological Activities Of Squalene,Potential Uses In Acute Myocardial Infarction

The main goal of this study is to investigate the effect of squalene on the improvement of clinical, laboratory and imaging symptoms in patients with acute heart failure due to acute myocardial infarction.

Clinical trial with a control group, with a parallel group, randomized, on 88 patients. The rand function of Excel software was used for randomization.

Patients with acute myocardial infarction who were admitted to Imam Reza Hospital randomly divided into two groups , receiving squalene drops in addition to routine treatments and a control group (only receiving treatment) routines). Also, treatment with squalene drops will be done 4 times a day with a dose of 5 drops each time for 5 days. Patients undergo hemodynamic, echocardiographic and necessary tests in the first 24 hours before starting the drug and then after 30 days.

The criteria for entering the study will be acute anterior myocardial infarction with an ejection fraction of less than 40%, who are admitted to Imam Reza Hospital. Patients with underlying kidney disease or underlying heart disease or a history of coronary bypass are excluded from the study.

Patients with anterior acute myocardial infarction with EF less than 40% who receive squalene in addition to routine treatments are the intervention group and patients with anterior acute infarction with ejection fraction less than 40% who are studied as control group and only conventional drugs And they receive routine heart disease, they are the control group of the study.

Echocardiographic parameters such as: ejection fraction, abnormality of valve motion, diastolic failure, pulmonary artery pressure, and valvular insufficiency. Hemodynamic parameters such as: initial blood pressure,presence or absence of pulmonary rales, blood oxygen saturation percentage.

First, the random sequence is generated using www.randomization.com. Then, based on the size of the research sample, a number of envelopes with aluminum wrappers (in order not to make the contents of the envelopes unclear) are prepared and each of the random sequences created is recorded on a card and the cards are placed inside the envelopes. In order to maintain the random sequence, the outer surface of the envelopes is numbered in the same order. Finally, the lids of the envelopes are glued and placed in a box. At the time of patient sampling, based on the order of entry of eligible participants into the study, one of the envelopes will be opened and the assigned group of that participant will be revealed.