Evaluating the effect of Oxytocin with Zinc sulphate on the withdrawal symptoms, craving, anxiety and reproductive indices in opiates addicted men under Methadone Maintenance Therapy

Evaluating the effect of Oxytocin with Zinc sulphate on the withdrawal symptoms, craving, anxiety and reproductive indices in opiates addicted men under Methadone Maintenance Therapy

In the outpatient treatment center, oxytocin nasal spray and normal saline nasal spray will have similar containers. Zinc sulfate and zinc sulfate placebo will have identical capsules. so that if If you don't refer to it, you can't understand which is real and which is placebo. The therapist and the patient will be unaware of the actual contents of the containers.

.At the outpatient treatment center, the people participating in the intervention will receive a coded package that, based on randomization, they have the possibility of being placed in the control or treatment group (coded by a third party), which the therapist and the patient seeker will not be aware of its actual content. They are aware that ultimately the code will determine whether the person received the actual treatment or a placebo

Entry requirements: According to the DSM-5, a person must qualify for opioid dependence be treated with methadone maintenance Have written consent Age between 20 and 50 years and should be literate Non-entry conditions: A person with suicidal thoughts, a history of any kind of blood, glandular, heart, lung, kidney disease, drug sensitivity, diabetes, major depressive disorder Individuals receiving glucocorticoid, serotonergic, or other antidepressant therapy

The intervention group includes MMT patients who will receive oxytocin nasal spray and zinc sulfate capsules The control group includes MMT patients who will receive saline nasal spray and zinc sulfate capsule placebo

oxytocin; zinc; withdrawal ; Craving Stress; anxiety; depression; testosterone; spermogram

First, using the Random number generation plugin in Excel software, a table of random numbers from 1 to 40 is prepared in a non-sequential and scattered manner, and intervention and control are done by assigning numbers to two groups of 20 people. The randomization process is done by the study consultant, and the clinical researchers do not know about the randomization process, and only randomized codes from 1 to 40 will be provided to them.

After selecting the samples, none of the sampled people will know about randomization and the process of allocation to groups. Researchers are given a table of coded numbers in advance, and patients are included in the study in the order of the numbers in the table. Therefore, the present study is double-blind. Oxytocin spray, zinc sulfate capsule, and placebo are both identical in shape, color, and size, and are delivered to the patient in a package.

The data should be such that they do not need additional explanation

Access starts six months after results are published

The data will be available only to researchers working in academic and scientific institutions.

It will be available to researchers in academic and scientific institutions for the purpose of research development.

A journal that works in the field of addiction and will accept the publication of research articles

According to the rules of the journal