Comparison of the effect of gargling rosemary extract and Ketamine on hoarseness and sore throat after tracheal intubation

Investigating the effect of rosemary gargle and ketamine on sore throat and hoarseness after tracheal intubation

A controlled, parallel-group, triple-blind, randomized, phase 2 clinical trial on 120 patients.

This is a three-blind randomized clinical trial that will be conducted on 120 general anesthesia candidates undergoing tracheal intubation in Al-Zahra Hospital, Isfahan. After the approval of the ethics committee of the university and obtaining the consent of the patients, the patients are randomly assigned into groups, in each group the desired intervention is applied and the clinical symptoms of the patient are recorded. The researcher who records the patient's symptoms, the analysts who collect the data analyzed during the study, and the patients did not know the type of intervention applied in each group, so they were all blind.

Inclusion criteria: age 18 to 65 years, ASA anesthesia class I and II, candidate for general anesthesia under tracheal intubation, and consent to participate in the study.Exclusion criteria: smoking and drug addiction, allergy to used drugs, diabetes, asthma and airway problems

Intervention group A: In this group, patients gargle 30 drops of rosemary solution (manufactured by Fadak Sepahan Pharmaceutical Company) dissolved in 30 ml of distilled water for 2-3 minutes before induction of anesthesia. Intervention group B: In this group, patients gargle 40 mg of Ketamine dissolved in 30 ml of distilled water for 30 seconds before induction of anesthesia. Intervention group C: In this group, patients gargle 30 ml of distilled water for 2-3 minutes before induction of anesthesia.

Sore throat, Hoarseness

Randomization is done in a simple way so that the patients are entered into groups A, B, and C according to the time of their arrival in the operating room, and this will continue until the number of patients in each group reaches 40 people.

This is a three-way blind clinical trial; In this way, the researcher who records the patient's symptoms is different from the person who prescribes the drug and has no knowledge of the type of drug and is blind. The analysts who analyze the data collected during the study also know the type of intervention. They don't have it in any group and they are blind. Even though the patients are included in the study, they do not know the type of intervention and are blind.